Han JunPyo, Jang Yujin, Shin Dong Yeop, Lee Jun, Seo Young Rok
Department of Life Science, Institute of Environmental Medicine for Green Chemistry, Dongguk University Biomedi Campus, Goyang, Korea.
J Cancer Prev. 2022 Dec 31;27(4):199-207. doi: 10.15430/JCP.2022.27.4.199.
As a principal component of solar radiation, ultraviolet B (UVB) exposure can be harmful depending on the duration and intensity because the human body can easily be exposed to it. Many studies have demonstrated that UVB causes a series of inflammatory and other skin disorders. UVB has been classified as the Group 1 carcinogen by the International Agency for Research on Cancer. Diverse studies have focused on UVB exposure but the complex perspective of acute and chronic UVB exposure is still lacking. This review presents the differences between acute and chronic exposure to UVB and summarizes public information in terms of toxicogenomic characteristics. We also demonstrated the differences between adverse effects of acute and chronic UVB exposure on the skin system. From the published literatures, we compared the biological pathways predict of the adverse effects caused by each UVB exposure type. Furthermore, our review not only clarifies the differences in each UVB exposure network but also suggests major hub genes related to cellular mechanisms and diseases that are thought to be affected by acute and chronic UVB exposure.
作为太阳辐射的主要成分，紫外线B（UVB）照射根据持续时间和强度可能是有害的，因为人体很容易暴露于其中。许多研究表明，UVB会引发一系列炎症和其他皮肤疾病。UVB已被国际癌症研究机构列为1类致癌物。众多研究聚焦于UVB照射，但急性和慢性UVB照射的综合视角仍较为缺乏。本综述阐述了急性和慢性UVB照射之间的差异，并从毒理基因组学特征方面总结了相关公开信息。我们还展示了急性和慢性UVB照射对皮肤系统的不良影响之间的差异。从已发表的文献中，我们比较了每种UVB照射类型所导致不良影响的生物途径预测。此外，我们的综述不仅阐明了每种UVB照射网络中的差异，还提出了与细胞机制和疾病相关的主要枢纽基因，这些基因被认为会受到急性和慢性UVB照射的影响。
