Gharaei Nejad Kaveh, Motamed Behrang, Hassanzadeh Rad Afagh, Rafiee Elahe, Dalili Setila, Molaei Atrie
Skin Research Center, Department of Dermatology, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Department of Internal Medicine, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Int J Endocrinol Metab. 2022 Oct 11;20(4):e128938. doi: 10.5812/ijem-128938. eCollection 2022 Oct.
Thyroid hormones are essential for the growth and maintenance of hair follicles. Numerous studies have evaluated the relationship between thyroid disorders and hair loss. However, no study has assessed the dermoscopic results in patients with hypothyroidism and hair loss.
This study aimed to investigate dermoscopic findings of alopecia in patients with hypothyroidism.
This analytic cross-sectional study was performed on patients with hair loss referred to dermatology clinics of Guilan University of Medical Sciences, Iran. Hypothyroid patients and an equal number of euthyroid individuals were compared. After recording the demographic and clinical characteristics, all patients were subjected to hair dermoscopy.
A total of 164 patients with and without hypothyroidism with hair loss were studied. The frequency of hair shaft abnormalities (P < 0.001) and vellus hair (P < 0.001) significantly differed between the two groups. Dermoscopic findings related to scale abnormalities (P = 0.002) and their perifollicular type (P < 0.001) significantly differed between the groups. Vascular changes (P < 0.001), perifollicular concentric type (P = 0.012), and interfollicular red loops type (P = 0.005) were significantly higher in patients with hypothyroidism. Also, based on the multiple logistic regression model, the chance of abnormalities of the hair shaft, scales, and vascular changes increased by 3.24, 2.73, and 3.53, respectively, in hypothyroidism compared to euthyroidism.
Regarding the promising results of this study, we could detect possible dermoscopic signs of inflammation in hypothyroid patients with hair loss. Further investigations are needed because there is a shortage of evidence on this novel diagnostic method.
甲状腺激素对毛囊的生长和维持至关重要。众多研究评估了甲状腺疾病与脱发之间的关系。然而，尚无研究评估甲状腺功能减退症患者脱发的皮肤镜检查结果。
本研究旨在调查甲状腺功能减退症患者脱发的皮肤镜检查结果。
对转诊至伊朗吉兰医科大学皮肤科诊所的脱发患者进行了这项分析性横断面研究。比较了甲状腺功能减退症患者和同等数量的甲状腺功能正常个体。记录人口统计学和临床特征后，所有患者均接受毛发皮肤镜检查。
共研究了164例有或无甲状腺功能减退症的脱发患者。两组之间毛干异常（P < 0.001）和毳毛（P < 0.001）的发生率有显著差异。两组之间与鳞屑异常（P = 0.002）及其毛囊周围类型（P < 0.001）相关的皮肤镜检查结果有显著差异。甲状腺功能减退症患者的血管变化（P < 0.001）、毛囊周围同心圆型（P = 0.012）和毛囊间红色环型（P = 0.005）显著更高。此外，基于多元逻辑回归模型，与甲状腺功能正常相比，甲状腺功能减退症患者毛干、鳞屑和血管变化异常的几率分别增加了3.24、2.73和3.53。
鉴于本研究的良好结果，我们能够在甲状腺功能减退症脱发患者中检测到可能的炎症皮肤镜征象。由于这种新型诊断方法的证据不足，需要进一步研究。
