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感染:临床特征与治疗综述

Infection: A Review of Clinical Features and Treatment.

作者信息

Yoshino Yusuke

机构信息

Teikyo University, School of Medicine, Department of Microbiology and Immunology, Tokyo, Japan.

出版信息

Infect Drug Resist. 2023 Jan 20;16:363-368. doi: 10.2147/IDR.S398739. eCollection 2023.

Abstract

Some species, including and , are increasingly becoming a common cause of nosocomial infections, accounting for the majority of human enterococcal infections, while other species, such as , have also been shown to be pathogenic to humans due to the increase in immunocompromised patients. These infections vary widely in their mode of transmission, symptoms, and other characteristics. Treatment is difficult in some cases because enterococci are resistant to numerous antimicrobial agents. and are the best-known opportunistic pathogens, but others, including , occasionally cause opportunistic infections. This review summarizes the clinical features of infections and discusses effective therapeutic strategies. Bacteremia was the most common form of infections. Because carries the VanC gene, which confers resistance to vancomycin, less resistant drugs such as ampicillin were found more effective in treating the bacteremia. The second most common form of infection was trauma-induced endophthalmitis. This was commonly reported in active young to middle-aged patients. Vitreoretinal surgery and local or systemic administration of sensitive antimicrobial agents seem to be key to successful treatment. Other conditions such as infective endocarditis, meningitis, peritonitis, and pyothorax have also been reported as forms of infection. This review clarifies the clinical features of infection and provides important insights into its treatment.

摘要

包括[具体物种1]和[具体物种2]在内的一些物种,正日益成为医院感染的常见原因,占人类肠球菌感染的大多数,而其他物种,如[具体物种3],由于免疫功能低下患者数量的增加,也已被证明对人类具有致病性。这些感染在传播方式、症状和其他特征方面差异很大。在某些情况下治疗很困难,因为肠球菌对多种抗菌药物具有抗性。[具体物种4]和[具体物种5]是最著名的机会致病菌,但其他物种,包括[具体物种6],偶尔也会引起机会性感染。本综述总结了[该物种]感染的临床特征,并讨论了有效的治疗策略。菌血症是[该物种]感染最常见的形式。由于[该物种]携带赋予对万古霉素抗性的VanC基因,发现如氨苄西林等抗性较小的药物在治疗菌血症方面更有效。[该物种]感染的第二常见形式是创伤性眼内炎。这在活跃的年轻至中年患者中普遍有报道。玻璃体视网膜手术以及局部或全身使用敏感抗菌药物似乎是成功治疗的关键。其他病症,如感染性心内膜炎、脑膜炎、腹膜炎和脓胸,也被报道为[该物种]感染的形式。本综述阐明了[该物种]感染的临床特征,并为其治疗提供了重要见解。

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