Hoshen Moshe, Shkalim Zemer Vered, Ashkenazi Shai, Grossman Zachi, Gerstein Maya, Yosef Noga, Cohen Moriya, Cohen Herman Avner
Dan-Petach Tikva District, Clalit Health Services, Petach Tikva, Israel.
Bioinformatics Department, Jerusalem College of Technology, Jerusalem, Israel.
Front Pediatr. 2023 Jan 13;10:1038308. doi: 10.3389/fped.2022.1038308. eCollection 2022.
Three aims: to elucidate determinants associated with COVID-19 vaccine uptake in children and the association with parental vaccination; to compare rates of PCR-positive SARS-CoV-2 results between vaccinated and unvaccinated children; to estimate the rate of parental COVID-19 vaccination and its association with the vaccination rate of their children.
We performed a retrospective chart review of all children aged 5-11 years registered at a central district in Israel from November 21st, 2021 to April 30th, 2022, and characterized COVID-19 vaccinated vs. unvaccinated individuals. Data retrieved from the electronic medical files included: demographics [age, gender, sector, socioeconomic status (SES)]; COVID-19 vaccination (first and second doses) and influenza vaccination status; co-morbidities; and parental vaccinations for COVID-19. We divided the population into three distinct demographic groups: non-ultra-orthodox Jews (43,889 children), ultra-orthodox Jews (13,858 children), and Arabs (4,029 children).
Of the 61,776 children included in the study, 20,355 (32.9%) received at least one dose of the COVID-19 vaccine. Vaccination rates were similar amongst males and females and were higher in children aged 9-11 years compared to children aged 5-6 years. Multivariate analysis identified five independent determinants that were significantly (< 0.001) associated with low vaccination rates: Arab and ultra-orthodox sectors (odds ratios: 0.235 and 0.617, respectively); children aged 5-8 years; children of low SES; and children who had not received previous seasonal influenza vaccination. Relatively high vaccination rates were noted amongst children with the following medical co-morbidities: treatment with biological agents (42.9%); solid tumor transplantation (42.9%); type 1 diabetes mellitus (38.5%), asthma (38.2%), and attention deficit and hyperactivity disorder (ADHD) (37.6%). Regarding the uptake of two vaccine doses among children with co-morbidities, it was highest in those with type 1 diabetes mellitus, heart failure, treatment with biological agents, asthma and obesity.
This study highlights several pediatric sub-populations with low and high vaccine uptake. It is essential to focus on determinants associated with low vaccination rates.
三个目标：阐明与儿童新冠疫苗接种相关的决定因素及其与父母接种情况的关联；比较接种疫苗和未接种疫苗儿童的新冠病毒聚合酶链反应（PCR）阳性结果发生率；估计父母新冠疫苗接种率及其与子女接种率的关联。
我们对2021年11月21日至2022年4月30日在以色列一个中心区登记的所有5至11岁儿童进行了回顾性病历审查，并对接种和未接种新冠疫苗的个体进行了特征描述。从电子病历中检索的数据包括：人口统计学信息（年龄、性别、教派、社会经济地位（SES））；新冠疫苗接种情况（第一剂和第二剂）和流感疫苗接种状况；合并症；以及父母的新冠疫苗接种情况。我们将人群分为三个不同人群：非极端正统派犹太人（43889名儿童）、极端正统派犹太人（13858名儿童）和阿拉伯人（4029名儿童）。
在纳入研究的61776名儿童中，20355名（32.9%）至少接种了一剂新冠疫苗。男性和女性的接种率相似，9至11岁儿童的接种率高于5至6岁儿童。多变量分析确定了五个与低接种率显著相关（<0.001）的独立决定因素：阿拉伯和极端正统派教派（比值比分别为0.235和0.617）；5至8岁儿童；社会经济地位低的儿童；以及之前未接种季节性流感疫苗的儿童。在患有以下合并症的儿童中，接种率相对较高：接受生物制剂治疗（42.9%）；实体瘤移植（42.9%）；1型糖尿病（38.5%）、哮喘（38.2%）和注意力缺陷多动障碍（ADHD）（37.6%）。关于合并症儿童中两剂疫苗的接种情况，1型糖尿病、心力衰竭、接受生物制剂治疗、哮喘和肥胖儿童的接种率最高。
本研究突出了疫苗接种率低和高的几个儿科亚人群。关注与低接种率相关的决定因素至关重要。
