Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O'Hara St, Pittsburgh, PA 15213, United States of America.
University of Arkansas for Medical Sciences School of Public Health, 4301 West Markham Street, Little Rock, AR 72205, United States of America.
Neurotoxicol Teratol. 2023 Mar-Apr;96:107162. doi: 10.1016/j.ntt.2023.107162. Epub 2023 Jan 27.
One in four Americans have used cannabidiol (CBD) products in the past year, and use has become prevalent in many Western countries with recent deregulation from a controlled or illicit substance to an unrestricted product. CBD is also marketed to pregnant people to treat common medical conditions. However, preclinical work has linked cannabidiol exposure to embryotoxicity, as well as neuroendocrine, reproductive, and behavioral effects in offspring. No studies have examined the prevalence or correlates of CBD use among pregnant people. Demographic, medical, and psychosocial correlates of cannabidiol use were examined in the YoungMoms study, a cohort of pregnant people under the age of 22, a population that is at high risk for cannabis use during pregnancy. Few of the participants (n = 186; 75% Black or Biracial) reported use of cannabidiol during pregnancy, but one in five had tried these products. Participants who reported ever using CBD were more likely to report alcohol and other drug use prior to pregnancy, controlling for race.As the use of CBD among people of reproductive age is increasingly prevalent, more research on CBD use in pregnant human populations is needed to investigate the effects of CBD on fetal development and infant outcomes.
四分之一的美国人在过去一年中使用过大麻二酚 (CBD) 产品,随着最近将其从受管制或非法物质转变为不受限制的产品,其使用在许多西方国家变得越来越普遍。CBD 也被推向孕妇市场,用于治疗常见的医疗状况。然而,临床前研究表明,大麻二酚暴露与胚胎毒性以及后代的神经内分泌、生殖和行为影响有关。目前还没有研究调查孕妇中 CBD 使用的流行率或相关因素。在 YoungMoms 研究中,对大麻二酚使用的人口统计学、医学和社会心理相关因素进行了研究,这是一个年龄在 22 岁以下的孕妇队列,该人群在怀孕期间使用大麻的风险很高。很少有参与者(n=186;75%为黑人或混血儿)报告在怀孕期间使用过 CBD,但五分之一的人曾尝试过这些产品。报告曾使用 CBD 的参与者在怀孕前更有可能报告使用酒精和其他药物,这与种族无关。随着 CBD 在育龄人群中的使用越来越普遍,需要对孕妇人群中 CBD 使用情况进行更多研究,以调查 CBD 对胎儿发育和婴儿结局的影响。