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语义性痴呆:一种复杂且受文化影响的表现形式。

Semantic dementia: a complex and culturally influenced presentation.

作者信息

Cole Richard H, Clark Camilla N, Poole Norman A

机构信息

Camden and Islington NHS Foundation Trust, London, UK and Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.

St George's University of London, London, UK.

出版信息

BJPsych Bull. 2024 Feb;48(1):44-50. doi: 10.1192/bjb.2022.100.

DOI:10.1192/bjb.2022.100
PMID:36718490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10801360/
Abstract

The variants of frontotemporal dementia (FTD) require careful differentiation from primary psychiatric disorders as the neuropsychiatric manifestations can overshadow the unique cognitive deficits. The language variants of FTD are less readily recognised by trainees despite making up around 43% of cases. This educational article presents an anonymised case of one of the language variants: semantic dementia. The cognitive deficits and neuropsychiatric manifestations (delusions and hyperreligiosity) are explored in terms of aetiology and management. By the end of the article, readers should be able to differentiate FTD from Alzheimer's disease, understand the principles of management and associated risks, and develop a multifaceted approach to hyperreligiosity in dementia.

摘要

额颞叶痴呆(FTD)的各种变体需要与原发性精神障碍仔细鉴别,因为神经精神症状可能会掩盖其独特的认知缺陷。尽管FTD的语言变体约占病例的43%,但实习医生较难识别。本文通过一个匿名病例介绍了其中一种语言变体:语义性痴呆。从病因和管理方面探讨了认知缺陷和神经精神症状(妄想和宗教狂热)。在文章结尾,读者应能够区分FTD与阿尔茨海默病,理解管理原则及相关风险,并制定针对痴呆患者宗教狂热的多方面应对方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c06/10801360/e2d2486320ae/S2056469422001000_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c06/10801360/da28665c75c4/S2056469422001000_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c06/10801360/e2d2486320ae/S2056469422001000_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c06/10801360/da28665c75c4/S2056469422001000_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c06/10801360/e2d2486320ae/S2056469422001000_fig2.jpg

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J Alzheimers Dis. 2021;79(4):1735-1745. doi: 10.3233/JAD-201088.
2
Semantic memory: A review of methods, models, and current challenges.语义记忆:方法、模型及当前挑战综述。
Psychon Bull Rev. 2021 Feb;28(1):40-80. doi: 10.3758/s13423-020-01792-x.
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New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures.额颞叶变性临床研究的新方向:方法和结果测量。
Alzheimers Dement. 2020 Jan;16(1):131-143. doi: 10.1016/j.jalz.2019.06.4956. Epub 2020 Jan 6.
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Late-onset psychosis and very-late-onset-schizophrenia-like-psychosis: an updated systematic review.迟发性精神病和极晚发性类似精神分裂症样精神病:一项更新的系统评价。
Int Rev Psychiatry. 2019 Aug-Sep;31(5-6):523-542. doi: 10.1080/09540261.2019.1670624. Epub 2019 Oct 10.
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Targeting prion-like protein spreading in neurodegenerative diseases.针对神经退行性疾病中朊病毒样蛋白的传播。
Neural Regen Res. 2018 Nov;13(11):1875-1878. doi: 10.4103/1673-5374.239433.
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Lancet Psychiatry. 2018 Jul;5(7):553-563. doi: 10.1016/S2215-0366(18)30141-X. Epub 2018 Jun 4.
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Neurotransmitter deficits from frontotemporal lobar degeneration.来自额颞叶变性的神经递质缺失。
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Semantic dementia and the left and right temporal lobes.语义性痴呆与左右颞叶
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