School of Chemistry and Chemical Engineering, Center on Nanoenergy Research, School of Physical Science and Technology, Guangxi University, Nanning 530004, P. R. China.
Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, P. R. China.
ACS Appl Mater Interfaces. 2023 Feb 15;15(6):7855-7866. doi: 10.1021/acsami.2c21878. Epub 2023 Jan 31.
The efficacy of cancer catalytic therapy is still hindered by the inefficient generation of reactive oxygen species (ROS). Herein, we report a self-driven electrical stimulation-promoted cancer catalytic therapy and chemotherapy by integrating a human-driven triboelectric nanogenerator (TENG) with an implantable and biodegradable nanofibrous patch. The gelatin/polycaprolactone nanofibrous patch incorporates doxorubicin (DOX) and graphitic carbon nitride (g-CN), in which the peroxidase (POD)-like activity of g-CN to produce hydroxyl radical (OH) can be distinctly enhanced by the self-driven electrical stimulation for 4.12-fold, and simultaneously DOX can be released to synergize the therapy, especially under a weakly acidic tumor microenvironment (TME) condition. The in vitro and in vivo experimental results on a mouse breast cancer model demonstrate superior tumor suppression outcome. The self-powered electrical stimulation-enhanced catalytic therapy and chemotherapy via multifunctional nanofibrous patches proposes a new complementary strategy for the catalytic therapy of solid tumors.
癌症催化疗法的疗效仍然受到活性氧（ROS）生成效率低下的限制。在此，我们报告了一种自驱动电刺激促进的癌症催化疗法和化疗，方法是将一个由人驱动的摩擦纳米发电机（TENG）与可植入和可生物降解的纳米纤维贴片集成在一起。该明胶/聚己内酯纳米纤维贴片包含阿霉素（DOX）和石墨相氮化碳（g-CN），其中 g-CN 的过氧化物酶（POD）样活性可以通过自驱动电刺激显著增强 4.12 倍，同时 DOX 可以释放出来以协同治疗，特别是在弱酸性肿瘤微环境（TME）条件下。在小鼠乳腺癌模型上的体外和体内实验结果表明，该疗法具有优越的肿瘤抑制效果。通过多功能纳米纤维贴片实现的自供电电刺激增强催化疗法和化疗为实体瘤的催化疗法提供了一种新的互补策略。
