• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

可生物降解聚合物依维莫司洗脱支架与当代药物洗脱支架的比较：系统评价和荟萃分析。

Biodegradable polymer everolimus-eluting stents versus contemporary drug-eluting stents: a systematic review and meta‑analysis.

机构信息

Department of Pharmacy, Huaihe Hospital, Henan University, Kaifeng, China.

Department of Cardiology, Huaihe Hospital, Henan University, Kaifeng, Henan, China.

出版信息

Sci Rep. 2023 Jan 31;13(1):1715. doi: 10.1038/s41598-022-26654-5.

DOI:10.1038/s41598-022-26654-5
PMID:36720978
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9889391/
Abstract

In spite of similar efficacy and safety in pilot studies, compared with the contemporary durable polymer drug-eluting stent (DP-DES), the bioabsorbable polymer drug-eluting stent (BP-DES) may be more superior in promoting blood vessel healing. We sought to compare the safety and efficacy of everolimus-eluting BP-DES (BP-EES) with contemporary DP-DES through a meta-analysis. We performed this meta-analysis to provide further evidence of the safety and efficacy of BP-EES. Medline, Embase and the Cochrane library databases were searched for randomized controlled trials comparing clinical efficacy and safety of BP-EES versus contemporary DP-DES. Fifteen RCTs with a total of 15,572 patients were selected. The rate of MACE was 9.4% in patients receiving BP-EES and 7.3% receiving DP-EES (RR 1.13, 95% CI 0.99-1.29, p = 0.05; I = 46%). TLF and MI were also similar in both groups. Based on the available data, this review demonstrates that BP-EES displays a clinically comparable efficacy and safety profile to that of contemporary DP-DES at years of follow-up in patients undergoing PCI.

摘要

尽管在试点研究中具有相似的疗效和安全性，但与当代持久聚合物药物洗脱支架（DP-DES）相比，可吸收聚合物药物洗脱支架（BP-DES）在促进血管愈合方面可能更具优势。我们通过荟萃分析比较了依维莫司洗脱 BP-DES（BP-EES）与当代 DP-DES 的安全性和疗效。我们进行这项荟萃分析是为了提供更多关于 BP-EES 安全性和疗效的证据。我们在 Medline、Embase 和 Cochrane 图书馆数据库中检索了比较 BP-EES 与当代 DP-DES 临床疗效和安全性的随机对照试验。共选择了 15 项 RCT，共有 15572 名患者。接受 BP-EES 治疗的患者的 MACE 发生率为 9.4%，接受 DP-EES 治疗的患者为 7.3%（RR 1.13，95%CI 0.99-1.29，p=0.05；I=46%）。TLF 和 MI 在两组中也相似。根据现有数据，本综述表明，在 PCI 患者的随访年中，BP-EES 显示出与当代 DP-DES 临床疗效和安全性相当的疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1469/9889391/0e9818149924/41598_2022_26654_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1469/9889391/a1ecf531d142/41598_2022_26654_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1469/9889391/5bf7327d6419/41598_2022_26654_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1469/9889391/28ecf2d13cd7/41598_2022_26654_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1469/9889391/1551b8103ce7/41598_2022_26654_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1469/9889391/91bd11452744/41598_2022_26654_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1469/9889391/0e9818149924/41598_2022_26654_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1469/9889391/a1ecf531d142/41598_2022_26654_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1469/9889391/5bf7327d6419/41598_2022_26654_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1469/9889391/28ecf2d13cd7/41598_2022_26654_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1469/9889391/1551b8103ce7/41598_2022_26654_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1469/9889391/91bd11452744/41598_2022_26654_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1469/9889391/0e9818149924/41598_2022_26654_Fig6_HTML.jpg

相似文献

1
Biodegradable polymer everolimus-eluting stents versus contemporary drug-eluting stents: a systematic review and meta‑analysis.可生物降解聚合物依维莫司洗脱支架与当代药物洗脱支架的比较：系统评价和荟萃分析。
Sci Rep. 2023 Jan 31;13(1):1715. doi: 10.1038/s41598-022-26654-5.
2
Comparison of the biodegradable polymer everolimus-eluting stent with contemporary drug-eluting stents: A systematic review and meta-analysis.比较可生物降解聚合物依维莫司洗脱支架与当代药物洗脱支架：系统评价和荟萃分析。
Int J Cardiol. 2019 Mar 1;278:51-56. doi: 10.1016/j.ijcard.2018.11.113. Epub 2018 Nov 23.
3
Clinical outcomes with bioabsorbable polymer- versus durable polymer-based drug-eluting and bare-metal stents: evidence from a comprehensive network meta-analysis.生物可吸收聚合物与耐用聚合物载药及裸金属支架的临床疗效：来自综合网络荟萃分析的证据。
J Am Coll Cardiol. 2014 Feb 4;63(4):299-307. doi: 10.1016/j.jacc.2013.09.061. Epub 2013 Nov 6.
4
Long-term safety of ultrathin bioabsorbable-polymer sirolimus-eluting stents versus thin durable-polymer drug-eluting stents in acute coronary syndrome: A systematic review and meta-analysis.超薄生物可吸收聚合物西罗莫司洗脱支架与薄型持久聚合物药物洗脱支架治疗急性冠状动脉综合征的长期安全性：系统评价和荟萃分析。
Clin Cardiol. 2023 Dec;46(12):1465-1473. doi: 10.1002/clc.24139. Epub 2023 Sep 3.
5
Biodegradable Polymer Biolimus-Eluting Stents Versus Durable Polymer Everolimus-Eluting Stents in Patients With Coronary Artery Disease: Final 5-Year Report From the COMPARE II Trial (Abluminal Biodegradable Polymer Biolimus-Eluting Stent Versus Durable Polymer Everolimus-Eluting Stent).生物可降解聚合物比伐卢定洗脱支架与耐久性聚合物依维莫司洗脱支架治疗冠状动脉疾病患者的比较：来自 COMPARE II 试验的最终 5 年报告（管腔生物可降解聚合物比伐卢定洗脱支架与耐久性聚合物依维莫司洗脱支架）。
JACC Cardiovasc Interv. 2017 Jun 26;10(12):1215-1221. doi: 10.1016/j.jcin.2017.02.029. Epub 2017 May 31.
6
Adverse cardiovascular events associated with biodegradable polymer drug-eluting stents and durable polymer everolimus-eluting stents: A systematic review and meta-analysis of 10 randomized controlled trials.与生物可降解聚合物药物洗脱支架和耐用聚合物依维莫司洗脱支架相关的不良心血管事件：对10项随机对照试验的系统评价和荟萃分析。
Medicine (Baltimore). 2017 Jul;96(28):e7510. doi: 10.1097/MD.0000000000007510.
7
Ultrathin Strut Biodegradable Polymer Sirolimus-Eluting Stent Versus Durable-Polymer Everolimus-Eluting Stent for Percutaneous Coronary Revascularization: 2-Year Results of the BIOSCIENCE Trial.用于经皮冠状动脉血运重建的超薄支柱可生物降解聚合物西罗莫司洗脱支架与耐用聚合物依维莫司洗脱支架对比：BIOSCIENCE试验的2年结果
J Am Heart Assoc. 2016 Mar 15;5(3):e003255. doi: 10.1161/JAHA.116.003255.
8
Safety and efficacy of the bioabsorbable polymer everolimus-eluting stent versus durable polymer drug-eluting stents in high-risk patients undergoing PCI: TWILIGHT-SYNERGY.在接受 PCI 的高危患者中，生物可吸收聚合物依维莫司洗脱支架与持久聚合物药物洗脱支架的安全性和疗效：TWILIGHT-SYNERGY 研究。
Catheter Cardiovasc Interv. 2021 Jan 1;97(1):63-71. doi: 10.1002/ccd.28995. Epub 2020 Jun 10.
9
Biodegradable polymer-coated thin strut sirolimus- -eluting stent versus durable polymer-coated everolimus-eluting stent in the diabetic population.生物可降解聚合物涂层薄支架西罗莫司洗脱支架与耐用聚合物涂层依维莫司洗脱支架在糖尿病患者中的比较。
Cardiol J. 2021;28(2):235-243. doi: 10.5603/CJ.a2019.0111. Epub 2020 Jan 7.
10
Very early neointimal coverage of new biodegradable polymer drug-eluting stent compared with durable polymer everolimus-eluting stent evaluated by optical frequency domain imaging.通过光学频域成像评估新型可生物降解聚合物药物洗脱支架与耐用聚合物依维莫司洗脱支架相比的极早期新生内膜覆盖情况。
Int J Cardiovasc Imaging. 2018 Apr;34(4):515-522. doi: 10.1007/s10554-017-1273-1. Epub 2017 Nov 20.

引用本文的文献

1
Preclinical Assessment of a Novel Polymer-Free Hybrid Drug Eluting Stent.新型无聚合物混合药物洗脱支架的临床前评估
J Cardiovasc Transl Res. 2025 Aug 15. doi: 10.1007/s12265-025-10680-5.
2
Drug-Eluting Stent Use in Percutaneous Coronary Interventions-A Narrative Review.药物洗脱支架在经皮冠状动脉介入治疗中的应用——一篇叙述性综述
J Clin Med. 2025 Jul 1;14(13):4643. doi: 10.3390/jcm14134643.
3
A self-sacrificing anti-inflammatory coating promotes simultaneous cardiovascular repair and reendothelialization of implanted devices.一种自我牺牲的抗炎涂层可促进植入装置的心血管修复和再内皮化同步进行。

本文引用的文献

1
Critical evaluation of stents in coronary angioplasty: a systematic review.经皮冠状动脉介入治疗中支架的评价：系统综述。
Biomed Eng Online. 2021 May 8;20(1):46. doi: 10.1186/s12938-021-00883-7.
2
Five-Year Comparative Efficacy of Everolimus-Eluting vs. Resolute Zotarolimus-Eluting Stents in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention.依维莫司洗脱支架与佐他莫司洗脱支架在接受经皮冠状动脉介入治疗的急性冠状动脉综合征患者中的五年疗效比较
J Clin Med. 2021 Mar 19;10(6):1278. doi: 10.3390/jcm10061278.
3
Biodegradable- Versus Durable-Polymer Drug-Eluting Stents for STEMI: Final 2-Year Outcomes of the BIOSTEMI Trial.
Bioact Mater. 2025 Feb 13;47:502-512. doi: 10.1016/j.bioactmat.2025.01.037. eCollection 2025 May.
4
Moving away from metal: Step toward the future with bioresorbable vascular scaffolds and novel antiproliferative agents.告别金属：借助生物可吸收血管支架和新型抗增殖药物迈向未来。
JVS Vasc Sci. 2024 Dec 18;6:100277. doi: 10.1016/j.jvssci.2024.100277. eCollection 2025.
生物可降解聚合物药物洗脱支架与耐久性聚合物药物洗脱支架治疗 ST 段抬高型心肌梗死：BIOSTEMI 试验的最终 2 年结果。
JACC Cardiovasc Interv. 2021 Mar 22;14(6):639-648. doi: 10.1016/j.jcin.2020.12.011.
4
Final 5-Year Results in Randomized Japanese Patients Implanted With a Thin-Strut, Bioabsorbable, Polymer-Coated, Everolimus-Eluting SYNERGY Stent (From the EVOLVE II Study).植入薄支柱、生物可吸收、聚合物涂层、依维莫司洗脱SYNERGY支架的日本随机患者的5年最终结果（来自EVOLVE II研究）
Circ Rep. 2020 Dec 11;3(1):9-17. doi: 10.1253/circrep.CR-20-0114.
5
PRISMA-S: an extension to the PRISMA Statement for Reporting Literature Searches in Systematic Reviews.PRISMA-S：用于在系统评价中报告文献检索的 PRISMA 声明的扩展。
Syst Rev. 2021 Jan 26;10(1):39. doi: 10.1186/s13643-020-01542-z.
6
Inflammation as a determinant of healing response after coronary stent implantation.炎症作为冠状动脉支架植入术后愈合反应的一个决定因素。
Int J Cardiovasc Imaging. 2021 Mar;37(3):791-801. doi: 10.1007/s10554-020-02073-3. Epub 2021 Jan 21.
7
Safety and performance of the EverPro everolimus-eluting coronary stent system with biodegradable polymer in a real-world scenario.依维莫司洗脱冠状动脉支架系统（EverPro）在真实临床环境中使用可生物降解聚合物的安全性和性能。
World J Cardiol. 2020 Dec 26;12(12):615-625. doi: 10.4330/wjc.v12.i12.615.
8
The role of residential history in cancer research: A scoping review.居住史在癌症研究中的作用：范围综述。
Soc Sci Med. 2021 Feb;270:113657. doi: 10.1016/j.socscimed.2020.113657. Epub 2020 Dec 25.
9
Feasibility, safety and long-term outcomes of complex left main bifurcation treatment using the nano-inverted-t stenting: a multicentre prospective registry.采用纳米倒置 T 支架治疗复杂左主干分叉病变的可行性、安全性和长期结果：一项多中心前瞻性注册研究。
Int J Cardiovasc Imaging. 2021 Apr;37(4):1107-1119. doi: 10.1007/s10554-020-02106-x. Epub 2020 Nov 16.
10
Ultrathin Bioresorbable-Polymer Sirolimus-Eluting Stents Versus Thin Durable-Polymer Everolimus-Eluting Stents for Coronary Revascularization: 3-Year Outcomes From the Randomized BIOFLOW V Trial.超薄生物可吸收聚合物西罗莫司洗脱支架与薄型持久聚合物依维莫司洗脱支架在冠状动脉血运重建中的比较：随机 BIOFLOW V 试验 3 年结果。
JACC Cardiovasc Interv. 2020 Jun 8;13(11):1343-1353. doi: 10.1016/j.jcin.2020.02.019.