Vazquez-Munoz Roberto, Thompson Angela, Russell Jordan T, Sobue Takanori, Zhou Yanjiao, Dongari-Bagtzoglou Anna
Department of Periodontology, University of Connecticut Health Center, Farmington, CT, United States.
Department of Psychiatry/Medicine, University of Connecticut Health Center, Farmington, CT, United States.
Front Microbiol. 2022 Mar 7;13:853762. doi: 10.3389/fmicb.2022.853762. eCollection 2022.
is a probiotic bacterial species with broad antimicrobial properties; however, its antimicrobial activities against the pathobiont are underexplored. The aim of this study was to study the interactions of with and explore mechanisms of bacterial anti-fungal activities based on bacterial genomic characterization coupled with experimental data. We isolated an strain (MT4) from the oral cavity of mice and characterized its effect on growth in the planktonic and biofilm states. We also identified key genetic and phenotypic traits that may be associated with a growth inhibitory activity exhibited against . We found that MT4 displays pH-dependent and pH-independent antagonistic interactions against , resulting in inhibition of planktonic growth and biofilm formation. This antagonism is influenced by nutrient availability and the production of soluble metabolites with anticandidal activity.
是一种具有广泛抗菌特性的益生菌物种；然而，其对致病共生菌的抗菌活性尚未得到充分研究。本研究的目的是研究与的相互作用，并基于细菌基因组特征结合实验数据探索细菌抗真菌活性的机制。我们从小鼠口腔中分离出一株菌株（MT4），并表征了其对浮游状态和生物膜状态下生长的影响。我们还确定了可能与对表现出的生长抑制活性相关的关键遗传和表型特征。我们发现MT4对表现出pH依赖性和非pH依赖性的拮抗相互作用，导致浮游生长和生物膜形成受到抑制。这种拮抗作用受营养物质可用性和具有抗念珠菌活性的可溶性代谢产物产生的影响。
