Insights From the Genome Suggest the Production of Metabolites With Antibiofilm Activity Against the Pathobiont .

is a probiotic bacterial species with broad antimicrobial properties; however, its antimicrobial activities against the pathobiont are underexplored. The aim of this study was to study the interactions of with and explore mechanisms of bacterial anti-fungal activities based on bacterial genomic characterization coupled with experimental data. We isolated an strain (MT4) from the oral cavity of mice and characterized its effect on growth in the planktonic and biofilm states. We also identified key genetic and phenotypic traits that may be associated with a growth inhibitory activity exhibited against . We found that MT4 displays pH-dependent and pH-independent antagonistic interactions against , resulting in inhibition of planktonic growth and biofilm formation. This antagonism is influenced by nutrient availability and the production of soluble metabolites with anticandidal activity.