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基于葡聚糖/琥铂酸 S-100 的氧化还原敏感纳米粒用于结直肠癌治疗。

Dextran/eudragit S-100 based redox sensitive nanoparticles for colorectal cancer therapy.

机构信息

School of Chemical Sciences and Advanced Materials Research Centre, Indian Institute of Technology Mandi, H.P.-175075, India.

Division of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

出版信息

Nanoscale. 2023 Feb 16;15(7):3273-3283. doi: 10.1039/d3nr00248a.

DOI:10.1039/d3nr00248a
PMID:36723053
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10061532/
Abstract

Herein, we present disulfide crosslinked dextran/eudragit S-100 nanoparticles (DEEU NPs) (≈55 nm) for colorectal cancer treatment. These redox environment sensitive DEEU NPs are synthesized by simple oxidation of thiolated polymers in air. This approach allows avoiding the use of any additional chemical crosslinker. These DEEU NPs have high encapsulation efficiency for the doxorubicin (DOX) model drug (≈95%). The prepared DEEU NPs are redox sensitive owing to disulfide units and exhibit ≈80% DOX release in the reducing environment of GSH. Additionally, DOX-DEEU NPs display enhanced cytotoxicity for HCT116 cancer cells as compared to free DOX. Annexin V staining results also support the higher anticancer efficiency of DOX-DEEU NPs induction of apoptosis. biodistribution results demonstrate that DEEU NPs can remain in the colon region for up to 24 hours. These results indicate that DEEU NPs can act as a promising platform for colorectal cancer treatment.

摘要

本文制备了一种用于结直肠癌治疗的二硫键交联葡聚糖/聚（甲基丙烯酸乙酯-共-甲基丙烯酸）纳米粒子（DEEU NPs）（≈55nm）。这些氧化还原敏感的 DEEU NPs 是通过在空气中对巯基化聚合物进行简单氧化合成的。该方法避免了使用任何额外的化学交联剂。这些 DEEU NPs 对阿霉素（DOX）模型药物具有高包封效率（≈95%）。由于二硫键单元的存在，所制备的 DEEU NPs 具有氧化还原敏感性，并在 GSH 的还原环境中表现出≈80%的 DOX 释放。此外，与游离 DOX 相比，DOX-DEEU NPs 对 HCT116 癌细胞表现出更高的细胞毒性。 Annexin V 染色结果也支持 DOX-DEEU NPs 通过诱导细胞凋亡具有更高的抗癌效率。 生物分布结果表明，DEEU NPs 可以在结肠区域停留长达 24 小时。这些结果表明，DEEU NPs 可以作为治疗结直肠癌的一种有前途的平台。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6fd/10061532/fdf02265e0ed/nihms-1873522-f0011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6fd/10061532/e279a7cb8b3f/nihms-1873522-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6fd/10061532/7b61775fff6d/nihms-1873522-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6fd/10061532/d6ccb5750e6a/nihms-1873522-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6fd/10061532/44e1631c38c7/nihms-1873522-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6fd/10061532/f2991c152ede/nihms-1873522-f0009.jpg
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