Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Bio-Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, P. R. China.
Biomater Sci. 2023 Mar 14;11(6):2080-2090. doi: 10.1039/d2bm01981g.
Bacterial infection and oxidative stress hinder clinical wound healing. Therefore, wound dressings with antibacterial and antioxidative properties are urgently needed. In this study, a type of quaternized lignin (QL) functionalized poly(hexamethylene biguanide) hydrochloride (PHMB) complex incorporated polyacrylamide (QL-PHMB-PAM) hydrogel was developed as a multifunctional dressing material for the promotion of infected wound repair. Owing to the abundant catechol groups of quaternized lignin, the QL-PHMB-PAM hydrogel exhibited robust repeatable adhesiveness to various substrates with antioxidative properties. Additionally, the antibacterial components of PHMB in the QL-PHMB-PAM composite hydrogel showed high efficiency and long-term antibacterial activity against , , and methicillin-resistant (; up to 100%). Furthermore, experiments indicated that this multifunctional hydrogel accelerated the healing of -infected wounds by promoting the reconstruction of blood vessels and hair follicles. These results demonstrate that this antioxidative, antibacterial, and bioadhesive hydrogel is a promising alternative wound dressing material for the prevention of bacterial infections and the acceleration of infected wound regeneration.
细菌感染和氧化应激会阻碍临床伤口愈合。因此，急需具有抗菌和抗氧化特性的伤口敷料。在这项研究中，开发了一种季铵化木质素 (QL) 功能化聚己二亚甲基双胍盐酸盐 (PHMB) 复合物掺入聚丙烯酰胺 (QL-PHMB-PAM) 水凝胶，作为一种多功能敷料材料，以促进感染性伤口修复。由于季铵化木质素中含有丰富的邻苯二酚基团，QL-PHMB-PAM 水凝胶具有对各种具有抗氧化性能的基底的强大可重复的粘附性。此外，PHMB 的抗菌成分在 QL-PHMB-PAM 复合水凝胶中对 、 、 和耐甲氧西林金黄色葡萄球菌（ ；长达 100%）表现出高效和长效的抗菌活性。此外， 实验表明，这种多功能水凝胶通过促进血管和毛囊的重建，加速感染伤口的愈合。这些结果表明，这种抗氧化、抗菌和生物粘附水凝胶是一种有前途的替代伤口敷料材料，可预防细菌感染并加速感染性伤口再生。
