Das Vishnu, Vinod Vivek, Biswas Lalitha, Kumar Anil, Biswas Raja
Amrita School of Nanosciences and Molecular medicine, Amrita Vishwa Vidyapeetham, AIMS, Ponekkara, Cochin 682041, India.
Department of Microbiology, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, AIMS, Ponekkara, Cochin 682041, India.
J Appl Microbiol. 2023 Jan 23;134(1). doi: 10.1093/jambio/lxac039.
Periodontitis is an inflammatory disease caused by microbial infections of the gum. At an advanced stage, periodontitis can even destroy the alveolar bone. Fusobacterium nucleatum, Prevotella intermedia, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Capnocytophaga gingivalis, and Pr. nigrescens are the major pathogens in periodontitis. Scaling and root planning are used together with local or systemic antibiotics to treat periodontitis. The difficulty in complete eradication of periodontal pathogens frequently leads to the relapse of the disease. As not many new antibiotics are available in the market, many researchers are now focusing on developing alternative strategies against periodontal microbes. This review provides an overview of the possible use of bacteriophages, lysins, honey, plant extracts, metallic salts, nanoparticles, and vaccines as alternative therapeutic agents against periodontal infections. The information provided here could help in designing alternative therapeutics for the treatment of periodontal infections.
牙周炎是一种由牙龈微生物感染引起的炎症性疾病。在晚期，牙周炎甚至会破坏牙槽骨。具核梭杆菌、中间普氏菌、伴放线聚集杆菌、牙龈卟啉单胞菌、牙龈二氧化碳嗜纤维菌和变黑普氏菌是牙周炎的主要病原体。龈下刮治术和根面平整术与局部或全身使用抗生素一起用于治疗牙周炎。彻底根除牙周病原体的困难常常导致疾病复发。由于市场上没有很多新的抗生素，许多研究人员现在正专注于开发对抗牙周微生物的替代策略。本综述概述了噬菌体、溶菌酶、蜂蜜、植物提取物、金属盐、纳米颗粒和疫苗作为对抗牙周感染的替代治疗剂的可能用途。此处提供的信息有助于设计治疗牙周感染的替代疗法。
