Deep learning for automatic mandible segmentation on dental panoramic x-ray images.

Many studies in the last decades have correlated mandible bone structure with systemic diseases like osteoporosis. Mandible segmentation, as well as segmentation of other oral structures, is an essential step in studies that correlate oral structures' conditions with systemic diseases in general. However, manual mandible segmentation is a time-consuming and training-required task that suffers from inter and intra-user variability. Further, the dental panoramic x-ray image (PAN), the most used image in oral studies, contains overlapping of many structures and lacks contrast on structures' interface. Those facts make both manual and automatic mandible segmentation a challenge. In the present study, we propose a precise and robust set of deep learning-based algorithms for automatic mandible segmentation (AMS) on PAN images. Two datasets were considered. An in-house image dataset with 393 image/segmentation pairs was prepared using image data of 321 image patient data and the corresponding manual segmentation performed by an experienced specialist. Additionally, a publicly available third-party image dataset (TPD) composed of 116 image/segmentation pairs was used to train the models. Four deep learning models were trained using U-Net and HRNet architectures with and without data augmentation. An additional morphological refinement routine was proposed to enhance the models' prediction. An ensemble model was proposed combining the four best-trained segmentation models. The ensemble model with morphological refinement achieved the highest scores on the test set (98.27%, 97.60%, 97.18%, ACC, DICE, and IoU respectively), with the other models scoring above 95% in all performance metrics on the test set. The present study achieved the highest ranked performance considering all the previously published results on AMS for PAN images. Additionally, those are the most robust results achieved since it was performed over an image set with considerable gender representativeness, a wide age range, a large variety of oral conditions, and images from different imaging scans.