Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, Hubei, PR China.
School of Rehabilitation Medicine, Binzhou Medical University, Yantai 264003, Shandong, PR China.
J Adv Res. 2023 Feb;44:81-90. doi: 10.1016/j.jare.2022.03.015. Epub 2022 Apr 6.
Nanozyme was considered as one of the most promising substitutes for antibiotics, due to the selective catalysis for pathogens. In this work, a high-antibacterial activity SOD-like nanozyme based on hybrid Ag/CeO nanocomposite was facilely prepared by using an innovative approach of selective laser welding in liquid. This prepared nanozyme displayed a high antimicrobial effect against Staphylococcus aureus under visible light illumination, the sterilization rate as high as 82.4%, which was 2.93 and 2.99 times higher than those of pure Ag and pure CeO, respectively. The enhanced antibacterial activity was attributed to the anchoring of Ag nanospheres on the surface of CeO nanosheets, which induced the reduction of CeO bandgap and boosted the visible light harvesting. Therefore, the charge carriers can be effectively stimulated to produce abundant reactive oxygen species on the Ag/CeO nanocomposite via a SOD-like route. This work demonstrated a facile strategy for the preparation of high-antibacterial activity nanozyme, giving it great potential for scalable application in the biomedical and pharmaceutical industry.
纳米酶被认为是抗生素最有前途的替代品之一，因为它对病原体具有选择性催化作用。在这项工作中，通过在液体中使用创新的选择性激光焊接方法，简便地制备了基于杂交 Ag/CeO 纳米复合材料的具有高抗菌活性的 SOD 样纳米酶。该纳米酶在可见光照射下对金黄色葡萄球菌表现出高抗菌效果，杀菌率高达 82.4%，分别比纯 Ag 和纯 CeO 高 2.93 和 2.99 倍。增强的抗菌活性归因于 Ag 纳米球在 CeO 纳米片表面的锚定，这诱导了 CeO 带隙的降低，并促进了可见光的捕获。因此，通过 SOD 样途径，电荷载流子可以在 Ag/CeO 纳米复合材料上被有效激发，从而产生丰富的活性氧物质。这项工作展示了一种简便的制备高抗菌活性纳米酶的策略，为其在生物医学和制药工业中的大规模应用提供了巨大的潜力。
