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[紫外线照射血液的生长刺激作用。I. 血液初始生长潜能及靶细胞功能状态的辐射剂量依赖性]

[Growth-stimulating effect of UF-irradiated blood. I. The radiation dose dependence of the initial growth potencies of blood and of the functional state of the target cells].

作者信息

Firulina I I, Samoĭlova K A, Belisheva N K

出版信息

Tsitologiia. 1987 Jul;29(7):818-24.

PMID:3672642
Abstract

UV irradiation (UVI) of donor blood in the apparatus used in hospitals of the USSR with the therapeutic aim of autotransfusion of UV-irradiated blood (AUVIB), results in an increase of connective tissue cell growth potency: being added into culture media the supernatants of irradiated blood stimulate DNA-synthetic and proliferative activity of cultured human embryonic cells. The high activity of cells persists for about 2 days. The effect is great with low initial levels of cell proliferative activity. In this case the effect is maximum (about 125% of the control). It is suggested that the above effect may be involved in the mechanism of stimulation of regeneration processes in the organism after AUVIB.

摘要

在苏联医院用于对紫外线照射血液进行自体输血(AUVIB)治疗目的的仪器中,对供血者血液进行紫外线照射(UVI),会导致结缔组织细胞生长能力增强:将照射后血液的上清液添加到培养基中,可刺激培养的人胚胎细胞的DNA合成和增殖活性。细胞的高活性持续约2天。在细胞增殖活性初始水平较低时,这种效果很显著。在这种情况下,效果达到最大值(约为对照组的125%)。有人认为,上述效果可能参与了AUVIB后机体再生过程的刺激机制。

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