Onn Wong Kwok, Woon Leo Lay, Leng Seah Huay
Food Control Division, Food and Veterinary Administration, Agri-Food and Veterinary Authority, Singapore.
Food Addit Contam. 2005 Mar;22(3):280-8. doi: 10.1080/02652030500077502.
The residual bisphenol A (BPA) levels in 28 different brands of polycarbonate (PC) baby milk bottles available in the Singapore market were measured. With a detection limit of 3 mg/kg, BPA residues were detected in 19 out of the 28 PC baby milk bottles at levels between 4.01 and 141 mg/kg, with a mean of 28.1 +/- 31.4 mg/kg and a median of 17.2 mg/kg. The potential migration of BPA from each of the 28 PC milk bottles was also measured using food-simulating solvents and time conditions recommended by the US Food and Drug Administration (US FDA), but using temperatures more severe than actual use. The highest upper-bound mean BPA migration levels of 0.64 +/- 0.48 microg/in2 in 10% ethanol at 70 degrees C and 0.43 +/- 1.25 microg/in2 in corn oil at 100 degrees C were observed after incubating cut portions of the milk bottles for 240 h. With this migration data and using US FDA's procedure for estimation of dietary exposure, the worst-case dietary exposure assessment for the intake of BPA by infants between birth and three months of age was below the oral Reference Dose of 0.05 mg/kg bw/day established by the US Environmental Protection Agency. This study showed that the dietary exposure to BPA from actual uses of PC milk bottles is unlikely to pose a health risk in infants.
对新加坡市场上28个不同品牌的聚碳酸酯（PC）婴儿奶瓶中的双酚A（BPA）残留量进行了测定。检测限为3毫克/千克，在28个PC婴儿奶瓶中的19个中检测到BPA残留，残留量在4.01至141毫克/千克之间，平均为28.1±31.4毫克/千克，中位数为17.2毫克/千克。还使用美国食品药品监督管理局（US FDA）推荐的食品模拟溶剂和时间条件，但采用比实际使用温度更严苛的温度，对28个PC奶瓶中的每一个进行了BPA潜在迁移量的测定。将奶瓶切割部分在70℃的10%乙醇中孵育240小时后，观察到最高的上限平均BPA迁移量为0.64±0.48微克/平方英寸；在100℃的玉米油中孵育240小时后，最高上限平均BPA迁移量为0.43±1.25微克/平方英寸。根据这些迁移数据，并采用US FDA的膳食暴露估计程序，对出生至三个月大婴儿摄入BPA的最坏情况膳食暴露评估低于美国环境保护局设定的口服参考剂量0.05毫克/千克体重/天。这项研究表明，婴儿实际使用PC奶瓶对BPA的膳食暴露不太可能对健康构成风险。
