Yan Shiyu, Zhao Jinfeng, Han Yuqing, Wang Rui, Bai Kexuan, Ge Junxin, Pan Yao, Zhao Hua
Department of Cosmetics, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing, 100048, People's Republic of China.
Beijing Key Laboratory of Plant Research and Development, Beijing, 100048, People's Republic of China.
Clin Cosmet Investig Dermatol. 2023 Jan 26;16:237-251. doi: 10.2147/CCID.S392925. eCollection 2023.
Sensitive skin (SS) is a common cutaneous condition that seriously affects people's quality of life, but studies of sensitive skin pathogenesis are unclear, the exploration are ongoing, and the biophysical properties of sensitive skin disagree with the study results. In this paper, we summarize the noninvasive biophysical and imaging instrumental methods used for sensitive skin and provide support for the classification of sensitive skin subtypes to prescribe precise treatment. PubMed and Web of Science databases were searched according to PRISMA guidelines for articles from January 1971 to May 2022 that used noninvasive biophysical or imaging methods to monitor adult subjects with sensitive skin. The quality of the included articles was determined based on 22 items of the STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) statement. A total of 55 studies were included, representing 8 biophysical and 5 imaging methods and their applications in treatment efficacy evaluation studies. The biophysical parameter and cutaneous morphological property changes in sensitive skin subjects were observed. The quality of the studies was relatively low, and there was high variability in results between studies. Several parameters have shown tremendous potential in exploring the pathogenesis with different sensitive skin subtypes: type I may be detected with higher transepidermal water loss and lower stratum corneum hydration values, as well as with thinner epidermis with a shallower and more irregular honeycomb structure; Type II and III are more prone to higher blood flow, lower current perception threshold than normal skin. This systematic review identifies key reasons for the lack of uniform trends in noninvasive measurements and recommends the use of effective selection instruments or relevant parameters to explore the pathogenesis of sensitive skin, and to differentiate the subtypes of sensitive skin for achieving the precise treatment.
敏感性皮肤（SS）是一种常见的皮肤状况，严重影响人们的生活质量，但关于敏感性皮肤发病机制的研究尚不清楚，仍在不断探索中，且敏感性皮肤的生物物理特性与研究结果不一致。在本文中，我们总结了用于敏感性皮肤的非侵入性生物物理和成像仪器方法，为敏感性皮肤亚型的分类提供支持，以便开出精准的治疗方案。根据PRISMA指南，检索了PubMed和Web of Science数据库中1971年1月至2022年5月期间使用非侵入性生物物理或成像方法监测成年敏感性皮肤受试者的文章。根据流行病学观察性研究报告强化声明（STROBE）的22项内容确定纳入文章的质量。共纳入55项研究，代表了8种生物物理方法、5种成像方法及其在治疗效果评估研究中的应用。观察了敏感性皮肤受试者的生物物理参数和皮肤形态学特性变化。研究质量相对较低，研究结果之间存在很大差异。几个参数在探索不同敏感性皮肤亚型的发病机制方面显示出巨大潜力：I型可能表现为经表皮水分流失较高、角质层水合值较低，以及表皮较薄，蜂巢结构较浅且更不规则；II型和III型比正常皮肤更容易出现血流增加、电流感知阈值降低。本系统评价确定了非侵入性测量缺乏统一趋势的关键原因，并建议使用有效的选择仪器或相关参数来探索敏感性皮肤的发病机制，并区分敏感性皮肤的亚型以实现精准治疗。
