Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands.
Department of Ophthalmology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Retina. 2023 Mar 1;43(3):379-388. doi: 10.1097/IAE.0000000000003686. Epub 2023 Jan 2.
A retrospective study was performed with data from the prospective randomized controlled trials, PLACE and SPECTRA, assessing the risk of foveal atrophy and the likelihood of structural and functional improvement on optical coherence tomography, after foveal half-dose photodynamic therapy in chronic central serous chorioretinopathy.
A total of 57 chronic central serous chorioretinopathy patients received a single half-dose photodynamic therapy with a treatment spot that included the fovea. Optical coherence tomography scans and fundus autofluorescence images were analyzed for structural improvement and possible atrophy development, at baseline and at several visits after treatment. Main outcome measures were integrity of the external limiting membrane and ellipsoid zone on optical coherence tomography and hypoautofluorescence on fundus autofluorescence.
The subfoveal external limiting membrane was graded as continuous in 21 of 57 of patients (36.8%) at baseline, and the subfoveal ellipsoid zone was graded as continuous in 5 of 57 patients (8.8%) at first visit, which improved to 50 of 51 (98.0%) and 32 out of 51 (62.7%) at the final visit at 2 years, respectively (both P < 0.001). Hypoautofluorescent changes on fundus autofluorescence were present in 25 of 55 patients (45.5%) at baseline and in 23 of 51 patients (45.1%) at the final visit ( P = 0.480).
In patients with chronic central serous chorioretinopathy who received a single, foveal, half-dose photodynamic therapy, a significant improvement in structure and function was seen at the final follow-up. None of the patients developed foveal atrophy.
通过对前瞻性随机对照试验 PLACE 和 SPECTRA 的数据分析，进行一项回顾性研究，评估在慢性中心性浆液性脉络膜视网膜病变中接受黄斑半剂量光动力疗法后，脉络膜视网膜的中心凹萎缩风险和光学相干断层扫描（OCT）下结构和功能改善的可能性。
57 例慢性中心性浆液性脉络膜视网膜病变患者接受了单次黄斑半剂量光动力疗法，治疗光斑包括中心凹。在基线和治疗后多次就诊时，对 OCT 扫描和眼底自发荧光图像进行分析，以评估结构改善和可能的萎缩发展情况。主要观察指标是 OCT 中外节膜的完整性和椭圆体带以及眼底自发荧光的低自发荧光。
57 例患者中有 21 例（36.8%）在基线时黄斑下的外节膜被评为连续，57 例中有 5 例（8.8%）在首次就诊时黄斑下的椭圆体带被评为连续，在 2 年的最终随访时分别改善至 51 例中的 50 例（98.0%）和 32 例（62.7%）（均 P<0.001）。55 例患者中有 25 例（45.5%）在基线时有低自发荧光改变，51 例中有 23 例（45.1%）在最终随访时有低自发荧光改变（P=0.480）。
在接受单次黄斑半剂量光动力疗法的慢性中心性浆液性脉络膜视网膜病变患者中，在最终随访时观察到结构和功能的显著改善。没有患者出现中心凹萎缩。
