Elfaki M G, Dawe D L, Murthy K K, Fletcher O J, Ragland W L
Department of Avian Medicine, College of Veterinary Medicine, University of Georgia, Athens 30605.
Vet Immunol Immunopathol. 1987 Sep;16(1-2):139-50. doi: 10.1016/0165-2427(87)90180-2.
Carrageenans (CGN), sulphated polygalactans, have been reported to be cytotoxic for macrophages in vitro. On this basis, the effect of the 3 major CGN types on humoral immune responses in chickens was investigated. Carrageenan had no effect on body and lymphoid organ weights. Histologically, CGN produced a significant proliferation of reticuloendothelial cells in liver and spleen, but no changes were observed in lymphocyte populations of the bursa of Fabricius, thymus, or spleen. Intracoelomic pretreatment with high doses of CGN induced a marked suppression of primary responses to sheep red blood cells (SRBC) given by the same route. However, if SRBC were injected intravenously into chickens already treated intracoelomically with CGN, no evidence of suppression was demonstrated. Antibody responses to Brucella abortus (BA), a T-independent antigen, were not affected by intracoelomic treatment with CGN. Intravenous pretreatment with CGN did not alter antibody responses to SRBC and BA given by the same route.
角叉菜胶（CGN），即硫酸化多聚半乳糖，据报道在体外对巨噬细胞具有细胞毒性。基于此，研究了3种主要类型的CGN对鸡体液免疫反应的影响。角叉菜胶对鸡的体重和淋巴器官重量没有影响。组织学检查显示，CGN使肝脏和脾脏中的网状内皮细胞显著增殖，但在法氏囊、胸腺或脾脏的淋巴细胞群体中未观察到变化。高剂量CGN腹腔内预处理可显著抑制通过相同途径给予绵羊红细胞（SRBC）的初次反应。然而，如果将SRBC静脉注射到已经腹腔内注射CGN的鸡体内，则未显示出抑制的迹象。对布鲁氏菌（BA）（一种非T细胞依赖性抗原）的抗体反应不受CGN腹腔内治疗的影响。CGN静脉内预处理不会改变通过相同途径给予SRBC和BA后的抗体反应。
