Faculdade de Motricidade Humana, Exercise and Health Laboratory, CIPER, Universidade de Lisboa Estrada da Costa, 1499-002, Cruz-Quebrada, Portugal.
CIDEFES - Centro de Investigação Em Desporto, Educação Física E Exercício E Saúde, Universidade Lusófona, Lisbon, Portugal.
Acta Diabetol. 2023 May;60(5):645-654. doi: 10.1007/s00592-023-02038-7. Epub 2023 Feb 2.
This investigation aimed to determine the effect of different intensities of training on non-exercise physical activity (NEPA) and estimated thermogenesis (NEAT) from a 1-year exercise randomized controlled trial (RCT) in individuals with type 2 diabetes mellitus (T2DM) on non-training days. Additionally, changes in NEPA and estimated NEAT in those who failed (low-responders) or succeeded (high-responders) in attaining exercise-derived clinically meaningful reductions in body weight (BW) and fat mass (FM) (i.e., 6% for FM and 3% for BW) was assessed.
Individuals with T2DM (n = 80) were enrolled in a RCT with three groups: resistance training combined with moderate-intensity continuous training (MICT) or high-intensity interval training (HIIT) and a control group. Of the 80 participants, 56 (completed data) were considered for this secondary analysis. NEPA and estimated NEAT were obtained by accelerometry and body composition through dual-energy X-ray absorptiometry.
After adjustments, no time*group interactions were found for estimated NEAT in the MICT (β = - 5.33, p = 0.366) and HIIT (β = - 5.70, p = 0.283), as well as for NEPA in the MICT (β = - 452.83, p = 0.833) and HIIT (β = - 2770.76, p = 0.201), when compared to controls. No compensatory changes in NEPA and estimated NEAT were observed when considering both low-responders and high-responders to FM and BW when compared to controls.
Both MICT and HIIT did not result in any compensatory changes in estimated NEAT and NEPA with the intervention on non-training days. Moreover, no changes in estimated NEAT and NEPA were found when categorizing our participants as low-responders and high-responders to FM and BW when compared to controls. Trial registration clinicaltrials.gov ID. NCT03144505.
本研究旨在确定不同强度训练对 2 型糖尿病（T2DM）患者非运动性身体活动（NEPA）和估计热量生成（NEAT）的影响，这些患者在非训练日接受了为期 1 年的运动随机对照试验（RCT）。此外，还评估了在未能（低反应者）或成功（高反应者）实现运动导致的体重（BW）和脂肪量（FM）临床显著降低（FM 降低 6%，BW 降低 3%）的参与者中，NEPA 和估计 NEAT 的变化。
将 80 名 T2DM 患者纳入 RCT 中，分为三组：抗阻训练联合中等强度持续训练（MICT）或高强度间歇训练（HIIT）和对照组。在 80 名参与者中，有 56 名（完成数据）被纳入此二次分析。通过加速度计和双能 X 射线吸收法测量身体成分来获得 NEPA 和估计的 NEAT。
调整后，MICT（β=-5.33，p=0.366）和 HIIT（β=-5.70，p=0.283）中估计的 NEAT 以及 MICT（β=-452.83，p=0.833）和 HIIT（β=-2770.76，p=0.201）中 NEPA 均未发现时间*组间交互作用与对照组相比。与对照组相比，当考虑到 FM 和 BW 的低反应者和高反应者时，NEPA 和估计的 NEAT 没有观察到代偿性变化。
MICT 和 HIIT 均未导致干预非训练日时估计的 NEAT 和 NEPA 发生任何代偿性变化。此外，与对照组相比，当将我们的参与者分为 FM 和 BW 的低反应者和高反应者时，没有发现估计的 NEAT 和 NEPA 发生变化。试验注册临床Trials.gov 标识符。NCT03144505。
