Hundeiker M
Fachklinik Hornheide an der Westfälischen Wilhelms-Universität Münster.
Z Hautkr. 1987 Aug 15;62(16):1197-204.
The term "prurigo" is universally used in dermatology. But, up to now, no definition of this term has been generally accepted. The "classic" description of the "urticarial papules" as the primary skin eruptions of prurigo is not correct, for these papules do not show any momentary edema but a persistent cellular infiltration. In the past, some authors already pointed out that the histologic structure of such papules looks very much like that of the characteristic papulovesicles in eczema--especially those in atopic dermatitis. The various forms of the prurigo nodes secondarily develop in case of the coincidence of three main factors: (1) the particular cutaneous response to repeated irritation (especially in autosomally dominant ichthyosis simplex), (2) reduced threshold for or constitutional disposition to pruritus (especially in atopy), and (3) internal (e.g. intestinal disorders) or external (e.g. insect bites) triggers. Probably none of the prurigo diseases represents a nosologic entity.
“痒疹”一词在皮肤病学中被广泛使用。但截至目前，该术语的定义尚未得到普遍认可。将“风团样丘疹”作为痒疹的原发性皮肤疹的“经典”描述并不正确，因为这些丘疹并无任何瞬间水肿，而是存在持续性细胞浸润。过去，一些作者已经指出，此类丘疹的组织学结构与湿疹中特征性的丘疹水疱非常相似——尤其是特应性皮炎中的丘疹水疱。痒疹结节的各种形式在三种主要因素同时出现时继发形成：（1）对反复刺激的特殊皮肤反应（尤其是在常染色体显性单纯性鱼鳞病中），（2）瘙痒阈值降低或对瘙痒的体质性倾向（尤其是在特应性中），以及（3）内部（如肠道疾病）或外部（如昆虫叮咬）触发因素。可能没有一种痒疹疾病代表一个病种实体。
