College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China; Luoyang Key Laboratory of Animal Genetics and Breeding, Luoyang 471023, China.
College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China; Luoyang Key Laboratory of Animal Genetics and Breeding, Luoyang 471023, China.
Virus Res. 2023 Mar;326:199057. doi: 10.1016/j.virusres.2023.199057. Epub 2023 Feb 3.
Porcine reproductive and respiratory syndrome (PRRS), caused by the PRRS virus (PRRSV), is an economically significant contagious disease. Traditional approaches based on vaccines or medicines were challenging to control PRRSV due to the diversity of viruses. Different breeds of pigs infected with PRRSV have been reported to have different immune responses. However, due to the complexity of interaction mechanism between host and PRRSV, the genetic mechanism leading to PRRSV susceptibility/resistance in various pig breeds is still unclear. Herein, the role of host genetic components in PRRSV susceptibility is systematically described, and the molecular mechanisms by which host genetic factors such as SNPs, cytokines, receptor molecules, intestinal flora, and non-coding RNAs regulate PRRSV susceptibility/resistance. Therefore, improving the resistance to disease of individual animals through disease-resistance breeding technology is of profound significance for uplifting the sustainable and healthy development of the pig industry.
猪繁殖与呼吸综合征（PRRS）由猪繁殖与呼吸综合征病毒（PRRSV）引起，是一种具有重大经济意义的传染性疾病。由于病毒的多样性，基于疫苗或药物的传统方法难以控制 PRRSV。不同品种的猪感染 PRRSV 后，其免疫反应不同。然而，由于宿主与 PRRSV 之间相互作用机制的复杂性，导致不同猪品种对 PRRSV 易感性/抗性的遗传机制仍不清楚。本文系统描述了宿主遗传成分在 PRRSV 易感性中的作用，以及 SNP、细胞因子、受体分子、肠道菌群和非编码 RNA 等宿主遗传因素调节 PRRSV 易感性/抗性的分子机制。因此，通过抗病育种技术提高个体动物对疾病的抗性，对提升猪产业的可持续健康发展具有深远意义。
