Department of Surgery, School of Medicine, Kyungpook National University Hospital, Kyungpook National University, Daegu, 41404, South Korea.
Department of Chemical Engineering, Wonkwang University, Iksan, Jeonbuk, 54538, South Korea.
Sci Rep. 2023 Feb 2;13(1):1880. doi: 10.1038/s41598-023-28113-1.
Endoscopic tattooing with India ink is a popular method for identifying colonic lesions during minimally invasive surgery because it is highly challenging to localize lesions during laparoscopy. However, there is a perceived unmet need for the injection of India ink and carbon particle suspension due to various complications and inconstant durability during the perioperative period. In this study, carbon black-containing self-healing adhesive alginate/polyvinyl alcohol composite hydrogels were synthesized as endoscopic tattooing inks. Alginate (Alg) conjugated with phenylboronic acid (PBA) groups in the backbone was crosslinked with polyvinyl alcohol (PVA) because of the dynamic bonds between the phenylboronic acid in alginate and the cis-diol groups of PVA. The carbon black-incorporated Alg-PBA/PVA hydrogels exhibited self-healing and re-shapable properties, indicating that improved intraoperative localization could be achieved. In addition, the adhesive tattooing hydrogels were stably immobilized on the target regions in the intraperitoneal spaces. These carbon black-containing self-healing adhesive hydrogels are expected to be useful in various surgical procedures, including endoscopic tattooing.
内镜下墨汁染色是一种在微创外科中识别结肠病变的常用方法，因为在腹腔镜下定位病变极具挑战性。然而，由于在围手术期存在各种并发症和不稳定性，人们认为需要注射墨汁和碳粒子悬浮液。在这项研究中，合成了含有炭黑的自修复型黏附性海藻酸钠/聚乙烯醇复合水凝胶作为内镜下染色墨水。由于海藻酸钠中的苯硼酸基团与聚乙烯醇中的顺式二醇基团之间存在动态键，因此带苯硼酸基团的海藻酸钠（Alg）与聚乙烯醇（PVA）交联。含有炭黑的 Alg-PBA/PVA 水凝胶表现出自修复和可再成型的特性，表明可以实现术中定位的改善。此外，黏附性纹身水凝胶可稳定地固定在腹腔内的目标区域。这些含有炭黑的自修复型黏附性水凝胶有望在各种手术过程中得到应用，包括内镜下染色。
