Clinical Department, Southern Urals Biophysics Institute, Ozyorsk, Chelyabinsk Region, Russia.
Biology and Environmental Chemistry Division, Sustainable System Research Laboratory, Central Research Institute of Electric Power Industry (CRIEPI), Tokyo, Japan.
Sci Rep. 2023 Feb 2;13(1):1926. doi: 10.1038/s41598-023-28954-w.
For improvement of the radiation protection system it is crucial to know the factors that modify the radiation dose-response relationship. One of such key factors is the ionizing radiation dose rate. There are, however, very few studies that examine the impact of the dose rate on radiogenic risks observed in human cohorts exposed to radiation at various dose rates. Here we investigated the impact of the dose rate (in terms of the recorded annual dose) on ischemic heart disease (IHD) mortality among Russian nuclear workers chronically exposed to radiation. We observed significantly increased excess relative risks (ERR) of IHD mortality per unit of external gamma-ray absorbed dose accumulated at higher dose rates (0.005-0.050 Gy/year). The present findings provide evidence for the association between radiation dose rate and ERRs of IHD mortality in occupationally chronically exposed workers per unit total dose. IHD mortality risk estimates considerably increased with increasing duration of uninterrupted radiation exposure at high rates. The present findings are consistent with other studies and can contribute to the scientific basis for recommendations on the radiation protection system.
为了改进辐射防护系统，了解改变辐射剂量-反应关系的因素至关重要。其中一个关键因素是电离辐射剂量率。然而，很少有研究考察剂量率对在不同剂量率下暴露于辐射的人类队列中观察到的放射性风险的影响。在这里，我们研究了剂量率（以记录的年剂量表示）对俄罗斯核工作人员慢性辐射暴露引起的缺血性心脏病（IHD）死亡率的影响。我们观察到，在较高剂量率（0.005-0.050 Gy/年）下，单位外γ射线吸收剂量累积时，IHD 死亡率的超额相对风险（ERR）显著增加。本研究结果为职业性慢性暴露工人单位总剂量的辐射剂量率与 IHD 死亡率 ERR 之间的关联提供了证据。IHD 死亡率风险估计随着高剂量率下不间断辐射暴露时间的延长而大幅增加。本研究结果与其他研究一致，可为辐射防护系统的建议提供科学依据。
