Department of Urology, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil.
Post Graduate Program in Medicine: Surgical Sciences, School of Medicine, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil.
BMC Endocr Disord. 2023 Feb 2;23(1):30. doi: 10.1186/s12902-023-01278-6.
Metabolic syndrome is a risk factor for several diseases. The relationship between metabolic syndrome and hypogonadism is well known. Our objetive is to assess whether a low carbohydrate diet can increase total serum testosterone and improve erectile function in hypogonadal men with metabolic syndrome.
An open label randomized clinical trial was conducted comparing a low carbohydrate diet and controls, during three months, in hypogonadal men with metabolic syndrome. Anthropometric measurements were evaluated as well as total serum testosterone levels, and symptoms of hypogonadism, using the ADAM and AMS scores, and sexual function using IIEF-5 score.
Eighteen men were evaluated. Anthropometric measures were improved only in low carbohydrate diet group. The intervention group also had a statistically increase in IIEF-5 score and a significant reduction in AMS and ADAM scores (p < 0.001). The increase in serum total testosterone levels was statistically significant in the low carbohydrate group compared to the control group as well as calculated free testosterone (p < 0.001).
Low carbohydrate diet may increase serum levels of testosterone and improve erectile function in hypogonadal men with metabolic syndrome. However, larger studies are necessary to strongly prove the effectiveness of low carbohydrate diet in treating male hypogonadism.
代谢综合征是多种疾病的危险因素。代谢综合征与性腺功能减退之间的关系是众所周知的。我们的目的是评估低碳水化合物饮食是否可以增加总血清睾酮并改善患有代谢综合征的性腺功能减退症男性的勃起功能。
进行了一项开放标签随机临床试验，比较了三个月内患有代谢综合征的性腺功能减退症男性的低碳水化合物饮食和对照组。评估了人体测量学测量值以及总血清睾酮水平，以及使用 ADAM 和 AMS 评分评估性腺功能减退症状，使用 IIEF-5 评分评估性功能。
评估了 18 名男性。仅在低碳水化合物饮食组中，人体测量学指标得到改善。干预组的 IIEF-5 评分也有统计学上的提高，AMS 和 ADAM 评分显著降低（p<0.001）。与对照组相比，低碳水化合物组的血清总睾酮水平升高具有统计学意义，游离睾酮水平也升高（p<0.001）。
低碳水化合物饮食可能会增加患有代谢综合征的性腺功能减退症男性的血清睾酮水平并改善勃起功能。然而，需要更大规模的研究来有力证明低碳水化合物饮食在治疗男性性腺功能减退症方面的有效性。
