Department of Biochemistry and Molecular Biology, Department of Physiology and Biomedical Engineering, Department of Transplantation, Mayo Clinic, Jacksonville, Florida, USA.
Skaggs Graduate School of Chemical and Biological Sciences, University of Florida Scripps Biomedical Research, Jupiter, Florida, USA.
J Extracell Vesicles. 2023 Feb;12(2):e12309. doi: 10.1002/jev2.12309.
Extracellular vesicles (EVs) are cell-released, heterogenous nanoparticles that play important roles in (patho)physiological processes through intercellular communication. EVs are often depicted as having a single lipid bilayer, but many studies have demonstrated the existence of multilayered EVs. There has been minimal inquiry into differences between unilamellar and multilamellar EVs in terms of biogenesis mechanisms and functional effects. This commentary speculates on potential causes and roles of multilamellar EVs and serves as a call to action for the research community to unravel the complex layers of EVs.
细胞外囊泡 (EVs) 是细胞释放的异质纳米颗粒，通过细胞间通讯在（病理）生理过程中发挥重要作用。EVs 通常被描绘为具有单层脂质双分子层，但许多研究已经证明了多层 EVs 的存在。关于在生物发生机制和功能效应方面，单层和多层 EVs 之间的差异，人们的研究很少。本评论推测了多层 EVs 的潜在原因和作用，并呼吁研究界揭开 EVs 的复杂层面。
