实施捐赠母乳计划后 <33 周胎龄或出生体重 <1500 克的新生儿的生长情况：回顾性队列研究。
Growth after implementing a donor breast milk program in neonates <33 weeks gestational age or birthweight <1500 grams: Retrospective cohort study.
机构信息
Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Division of Neonatology, Joe DiMaggio Children's Hospital, Hollywood, FL, USA.
出版信息
J Perinatol. 2023 May;43(5):608-615. doi: 10.1038/s41372-023-01627-2. Epub 2023 Feb 3.
BACKGROUND
Donor breast milk (DBM) feeding has been associated with less growth than formula in preterm infants. Zinc content in DBM is insufficient to support growth in preterm infants.
OBJECTIVE
To compare growth from birth to discharge, macro- and micronutrient intake and the frequency of poor growth before (Epoch-1) and after (Epoch-2) implementing a DBM program.
METHODS
Retrospective cohort study of 1069 infants born at < 33 weeks' gestational age or birthweight < 1500 g and fed using our adjustable feeding protocol with accurate serial length measurements. Growth was assessed by changes in Z-scores of weight, length and fronto-occipital circumference from birth to discharge.
RESULTS
Growth did not decrease significantly in Epoch-2. However, energy and protein intake increased by 5% and frequency of zinc and vitamin D supplementation increased by >30%.
CONCLUSIONS
DBM implementation did not significantly decrease growth from birth to discharge using our adjustable feeding protocol.
背景
与配方奶相比，捐赠母乳（DBM）喂养会导致早产儿生长较慢。DBM 中的锌含量不足以支持早产儿的生长。
目的
比较从出生到出院的生长情况、宏量和微量营养素的摄入量，以及在实施 DBM 计划之前（Epoch-1）和之后（Epoch-2）生长不良的频率。
方法
对 1069 名胎龄<33 周或出生体重<1500g 的早产儿进行回顾性队列研究，使用我们的可调节喂养方案进行喂养，并进行准确的连续长度测量。通过出生至出院时体重、长度和头围 Z 分数的变化来评估生长情况。
结果
在 Epoch-2 中，生长并没有显著下降。然而，能量和蛋白质的摄入量增加了 5%，锌和维生素 D 补充的频率增加了>30%。
结论
使用我们的可调节喂养方案，实施 DBM 并不会显著降低从出生到出院的生长速度。
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