Experimental Nutrition Laboratory, Department of Nutrition, Federal University of Paraíba (UFPB), João Pessoa, Paraíba, Brazil; Post Graduate Program in Nutrition Sciences, Federal University of Paraíba (UFPB), João Pessoa, Paraíba, Brazil.
Experimental Nutrition Laboratory, Department of Nutrition, Federal University of Paraíba (UFPB), João Pessoa, Paraíba, Brazil.
Food Res Int. 2023 Feb;164:112391. doi: 10.1016/j.foodres.2022.112391. Epub 2022 Dec 31.
Malícia honey produced by the jandaíra bee has hypoglycaemic and hypolipidemic effects and antioxidant activity in vitro and in vivo, which makes it potential adjuvant treatment for obesity. This study aimed to evaluate the effects of malícia honey on somatic and biochemical parameters, depressive-like behaviour and anti-inflammatory activity in obese rats. A total of 40 adult male Wistar rats were initially randomized into a healthy group (HG, n = 20) that consumed a control diet, and an obese group (OG, n = 20) which consumed a cafeteria diet for eight weeks. Then, they were subdivided into four groups: healthy (HG, n = 10); healthy treated with malícia honey (HGH, n = 10); obese (OG, n = 10); and obese treated with malícia honey (OGH, n = 10), maintaining their diets for another eight weeks. The HGH and OGH groups received malícia honey (1000 mg/kg body weight) via gavage. Food intake was monitored daily and body weight was monitored weekly. Biochemical tests related to obesity and glucose and insulin tolerance test, somatic parameters, histological parameters and quantification of NF-κB in the brain were performed. Treatment with malícia honey improved depressive-like behaviour, reduced weight (14 %), body mass index (6 %), and improved lipid profile, leptin, insulin, HOMA-β, and glucose and insulin tolerance in obese rats. It also decreased NF-κB (58.08 %) in the brain. Malícia honey demonstrated anti-obesity and anti-inflammatory effects, and reversed changes in obesity-induced depressive-like behaviour.
马利西亚蜂蜜具有降血糖、降血脂和抗氧化作用，在体内外均具有活性，这使其成为肥胖症的潜在辅助治疗方法。本研究旨在评估马利西亚蜂蜜对肥胖大鼠的体躯和生化参数、抑郁样行为和抗炎活性的影响。共 40 只成年雄性 Wistar 大鼠最初随机分为健康组（HG，n=20）和肥胖组（OG，n=20），健康组摄食对照饮食，肥胖组摄食自助餐饮食 8 周。然后，它们被分为四组：健康组（HG，n=10）；健康组接受马利西亚蜂蜜治疗（HGH，n=10）；肥胖组（OG，n=10）；肥胖组接受马利西亚蜂蜜治疗（OGH，n=10），并维持各自的饮食 8 周。HGH 和 OGH 组通过灌胃给予马利西亚蜂蜜（1000mg/kg 体重）。每天监测食物摄入量，每周监测体重。进行与肥胖相关的生化测试和葡萄糖及胰岛素耐量试验、体躯参数、组织学参数和大脑中 NF-κB 的定量分析。马利西亚蜂蜜治疗改善了肥胖大鼠的抑郁样行为，降低了体重（14%）、体重指数（6%），改善了肥胖大鼠的血脂谱、瘦素、胰岛素、HOMA-β、葡萄糖和胰岛素耐量，并降低了大脑中的 NF-κB（58.08%）。马利西亚蜂蜜具有抗肥胖和抗炎作用，并逆转了肥胖诱导的抑郁样行为的变化。
