脑内动态 N6-甲基腺苷 RNA 甲基化与疾病。
Dynamic N6-methyladenosine RNA methylation in brain and diseases.
机构信息
Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA.
出版信息
Epigenomics. 2020 Feb;12(4):371-380. doi: 10.2217/epi-2019-0260. Epub 2020 Feb 21.
Abstract
N6-methyladenosine (mA) is a dynamic RNA modification that regulates various aspects of RNA metabolism and has been implicated in many biological processes and transitions. mA is highly abundant in the brain; however, only recently has the role of mA in brain development been a focus. The machinery that controls mA is critically important for proper neurodevelopment, and the precise mechanisms by which mA regulates these processes are starting to emerge. However, the role of mA in neurodegenerative and neuropsychiatric diseases still requires much elucidation. This review discusses and summarizes the current body of knowledge surrounding the function of the mA modification in regulating normal brain development, neurodegenerative diseases and outlines possible future directions.
摘要
N6-甲基腺苷（m6A）是一种动态的 RNA 修饰，可调节 RNA 代谢的各个方面，并与许多生物学过程和转变有关。m6A 在大脑中含量丰富；然而，m6A 在大脑发育中的作用最近才成为研究重点。调控 m6A 的机制对神经发育至关重要，m6A 调控这些过程的确切机制开始显现。然而，m6A 在神经退行性疾病和神经精神疾病中的作用仍需要进一步阐明。本文讨论并总结了目前关于 m6A 修饰在调节正常大脑发育、神经退行性疾病中的功能的知识体系，并概述了可能的未来方向。
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