Farrell F J
Allergy and Clinical Immunology, Mercy Hospital, Watertown, NY.
Am J Ind Med. 1987;12(3):331-7. doi: 10.1002/ajim.4700120308.
IgE-mediated acute and late phase reactions associated with occupational metal fume exposure are rare compared with the more common metal fume fever. The latter is a common acute industrial disease caused by inhalation of oxides of metals, especially zinc. It is a flu-like illness and is thought to be self-limited. This article describes the first case, to my knowledge, of an immediate and a late phase reaction (urticaria and angioedema) to zinc fumes, associated with a metal fume fever-like reaction. Hives and angioedema developed immediately and in a delayed fashion in a 34-year-old man after he had welded zinc at his job. There also was an associated metal fume fever-like reaction. The relationship was proved by a challenge test done at home. The patient has been asymptomatic since using complete protective measures while welding zinc. Possible immunologic mechanisms are discussed.
与较为常见的金属烟热相比，由IgE介导的、与职业性金属烟雾暴露相关的速发和迟发反应较为罕见。后者是一种常见的急性职业病，由吸入金属氧化物尤其是锌的氧化物引起。它是一种类似流感的疾病，被认为是自限性的。据我所知，本文描述了首例与金属烟热样反应相关的对锌烟雾的速发和迟发反应（荨麻疹和血管性水肿）。一名34岁男性在工作中焊接锌后，立即出现荨麻疹和血管性水肿，并呈延迟性发作。同时还伴有金属烟热样反应。在家中进行的激发试验证实了这种关联。自该患者在焊接锌时采取了完全的防护措施后，一直没有症状。文中还讨论了可能的免疫机制。
