Xing N, Huo R, Wang H T, Yang J C, Chen J, Peng L, Liu X W
Department of Burn and Plastic Surgery, Weihai Municipal Hospital, Shandong University, Weihai 264200, China.
Department of Plastic and Cosmetic Surgery, Shandong Provincial Hospital, Shandong University, Jinan 250021, China.
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2023 Jan 20;39(1):81-84. doi: 10.3760/cma.j.cn501120-20211204-00404.
In recent years, with the problem of aging population in China being prominant, the number of patients with chronic wounds such as diabetic foot, pressure ulcer, and vascular ulcer is increasing. Those diseases seriously affect the life quality of patients and increase the economy and care burden of the patients' family, which have been one of the most urgent clinical problems. Many researches have confirmed that adipose stem cells can effectively promote wound healing, while exogenous protease is needed, and there are ethical and many other problems, which limit the clinical application of adipose stem cells. Adipose stem cell matrix gel is a gel-like mixture of biologically active extracellular matrix and stromal vascular fragment obtained from adipose tissue by the principle of fluid whirlpool and flocculation precipitation. It contains rich adipose stem cells, hematopoietic stem cells, endothelial progenitor cells, and macrophages, etc. The preparation method of adipose stem cell matrix gel is simple and the preparation time is short, which is convenient for clinical application. Many studies at home and abroad showed that adipose stem cell matrix gel can effectively promote wound healing by regulating inflammatory reaction, promoting microvascular reconstruction and collagen synthesis. Therefore, this paper summarized the preparation of adipose stem cell matrix gel, the mechanism and problems of the matrix gel in promoting wound repair, in order to provide new methods and ideas for the treatment of chronic refractory wounds in clinic.
近年来，随着我国人口老龄化问题日益突出，糖尿病足、压疮、血管性溃疡等慢性创面患者数量不断增加。这些疾病严重影响患者生活质量，加重患者家庭的经济和护理负担，已成为临床亟待解决的问题之一。诸多研究证实，脂肪干细胞能有效促进创面愈合，但需要外源性蛋白酶，且存在伦理等诸多问题，限制了脂肪干细胞的临床应用。脂肪干细胞基质凝胶是通过流体漩涡和絮凝沉淀原理从脂肪组织中获得的具有生物活性的细胞外基质与基质血管片段的凝胶状混合物。它含有丰富的脂肪干细胞、造血干细胞、内皮祖细胞和巨噬细胞等。脂肪干细胞基质凝胶的制备方法简单，制备时间短，便于临床应用。国内外多项研究表明，脂肪干细胞基质凝胶可通过调节炎症反应、促进微血管重建和胶原蛋白合成来有效促进创面愈合。因此，本文综述了脂肪干细胞基质凝胶的制备、基质凝胶促进创面修复的机制及存在的问题，以期为临床治疗慢性难愈创面提供新的方法和思路。
