Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 Xiwu Road, Xi'an, 710004, China.
State Key Laboratory of Multiphase Flow in Power Engineering, Xi'an Jiaotong University, Xi'an, 710049, Shaanxi, China.
Lasers Med Sci. 2023 Feb 6;38(1):64. doi: 10.1007/s10103-023-03724-2.
To identify factors influencing the efficacy of Q-switched laser in the treatment of naevus of Ota in children and to compare the efficacy, safety, and recurrence rate between 1064 nm Q-switched Nd:YAG laser (QSNL) and 755 nm Q-switched alexandrite laser (QSAL). We retrospectively analysed 160 children with naevus of Ota who completed QSAL or QSNL laser treatment at our centre. Age at initial treatment (P = 0.004), colour of lesions (P = 0.025), and number of treatments (P = 0.002) were related to efficacy. Compared with patients aged 0-11 months at initial treatment, patients who started treatment at 1-3 years (OR adj = 0.47), 4-8 years (OR adj = 0.20), and 9-12 years (OR adj = 0.27) had inferior efficacy. The efficacy of brown-violet (OR adj = 2.67) and blue-violet lesions (OR adj = 2.51) was better than that of brown lesions. Moreover, patients who received 3-4 (OR adj = 2.83) or 5-6 (OR adj = 7.35) treatment sessions showed a better response than those who received 1-2 sessions. Additionally, as the age at initial treatment increased, the rate of complications increased from 2.0 to 14.3%, while the recurrence rate decreased from 8.2 to 0%. In addition, the complication rate increased with an increase in the number of treatments. There were no significant differences in clinical efficacy (P = 0.94), risk of complications (P = 0.752), or recurrence (P = 0.834) between QSAL and QSNL for treating naevus of Ota in children. QSAL and QSNL are equally effective for children's naevus of Ota, with low complications and recurrence rates. Younger age at initial treatment and a greater number of treatments are beneficial for efficacy, whereas brown lesions are a negative factor.
探讨影响儿童太田痣 Q 开关激光疗效的因素，并比较 1064nm Q 开关 Nd：YAG 激光（QSNL）与 755nm Q 开关翠绿宝石激光（QSAL）的疗效、安全性和复发率。方法：回顾性分析 160 例在我中心接受 QSAL 或 QSNL 激光治疗的太田痣患儿的临床资料。结果：初始治疗年龄（P=0.004）、皮损颜色（P=0.025）和治疗次数（P=0.002）与疗效相关。与初始治疗时年龄为 0-11 个月的患儿相比，初始治疗时年龄为 1-3 岁（OR 调整=0.47）、4-8 岁（OR 调整=0.20）和 9-12 岁（OR 调整=0.27）的患儿疗效较差。棕色-紫色（OR 调整=2.67）和蓝紫色皮损（OR 调整=2.51）的疗效优于棕色皮损。此外，接受 3-4 次（OR 调整=2.83）或 5-6 次（OR 调整=7.35）治疗的患儿疗效优于接受 1-2 次治疗的患儿。另外，随着初始治疗年龄的增加，并发症发生率从 2.0%增加至 14.3%，而复发率从 8.2%降至 0%。此外，随着治疗次数的增加，并发症发生率也随之增加。QSAL 和 QSNL 治疗儿童太田痣的临床疗效（P=0.94）、并发症风险（P=0.752）和复发率（P=0.834）差异均无统计学意义。结论：QSAL 和 QSNL 治疗儿童太田痣疗效相当，并发症和复发率均较低。初始治疗年龄较小、治疗次数较多有利于提高疗效，而棕色皮损是不利因素。
