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低剂量紫杉醇促进脊髓损伤后神经元轴突的延伸和功能恢复。

Low-Dose Taxol Promotes Neuronal Axons Extension and Functional Recovery after Spinal Cord Injury.

机构信息

College of Pharmacy, Jilin University, Changchun 130021, China.

Xuanwu Hospital Capital Medical University, Beijing 100053, China.

出版信息

Mediators Inflamm. 2023 Jan 27;2023:5604103. doi: 10.1155/2023/5604103. eCollection 2023.

DOI:10.1155/2023/5604103
PMID:36741075
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9897914/
Abstract

Axonal regeneration has been the research focus in the field of clinical treatment for spinal cord injury (SCI). The growth and extension of neuronal axons is a dynamic biological process mediated by the cytoskeleton, and microtubule plays an important role in axonal growth. Moderate stabilization of microtubule promotes axonal growth and eliminates various intra- and extracellular mechanisms that impede axonal regeneration. After SCI, the damaged axons rapidly form a growth cone, wherein the stability of tubulin decreases, impairing axonal regeneration. Taxol with proven clinical safety is commonly used as a broad-spectrum antitumor drug. Importantly, Taxol can promote axonal extension by enhancing and stabilizing the microtubule assembly. In our study, we systematically investigated the differentiation of neural stem cells (NSCs) and functional recovery in injured rats following Taxol treatment. Low-dose Taxol promoted differentiation of NSCs to neurons and significantly extended the axons . , Taxol promoted the expression of III-tubulin in the injured areas and motor function recovery after SCI. Low-dose Taxol is a promising clinical agent to promote axonal regeneration after SCI.

摘要

轴突再生一直是脊髓损伤 (SCI) 临床治疗领域的研究重点。神经元轴突的生长和延伸是一个由细胞骨架介导的动态生物学过程，微管在轴突生长中起着重要作用。适度稳定微管可促进轴突生长，并消除各种阻碍轴突再生的内外机制。SCI 后，受损的轴突迅速形成生长锥，其中微管蛋白的稳定性降低，损害了轴突的再生。紫杉醇已被证明具有临床安全性，通常被用作广谱抗肿瘤药物。重要的是，紫杉醇可以通过增强和稳定微管组装来促进轴突延伸。在我们的研究中，我们系统地研究了紫杉醇处理后神经干细胞 (NSC) 的分化和损伤大鼠的功能恢复。低剂量紫杉醇促进 NSCs 向神经元分化，并显著延长轴突。紫杉醇还促进了损伤区域 III 微管蛋白的表达和 SCI 后的运动功能恢复。低剂量紫杉醇是一种很有前途的临床药物，可促进 SCI 后的轴突再生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cbf/9897914/13971018c1d1/MI2023-5604103.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cbf/9897914/22e0f1769314/MI2023-5604103.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cbf/9897914/59603a0d2af3/MI2023-5604103.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cbf/9897914/c86736000942/MI2023-5604103.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cbf/9897914/975c2f9dbd03/MI2023-5604103.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cbf/9897914/e54f7ff7ca14/MI2023-5604103.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cbf/9897914/13971018c1d1/MI2023-5604103.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cbf/9897914/22e0f1769314/MI2023-5604103.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cbf/9897914/59603a0d2af3/MI2023-5604103.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cbf/9897914/c86736000942/MI2023-5604103.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cbf/9897914/975c2f9dbd03/MI2023-5604103.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cbf/9897914/e54f7ff7ca14/MI2023-5604103.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cbf/9897914/13971018c1d1/MI2023-5604103.006.jpg

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