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纹状体直接和间接通路中D1和D2多巴胺受体的分离：历史视角

Segregation of D1 and D2 dopamine receptors in the striatal direct and indirect pathways: An historical perspective.

作者信息

Gerfen Charles R

机构信息

Section on Neuroanatomy, National Institute of Mental Health (NIMH), Bethesda, MD, United States.

出版信息

Front Synaptic Neurosci. 2023 Jan 19;14:1002960. doi: 10.3389/fnsyn.2022.1002960. eCollection 2022.

DOI:10.3389/fnsyn.2022.1002960
PMID:36741471
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9892636/
Abstract

The direct and indirect striatal pathways form a cornerstone of the circuits of the basal ganglia. Dopamine has opponent affects on the function of these pathways due to the segregation of the D1- and D2-dopamine receptors in the spiny projection neurons giving rise to the direct and indirect pathways. An historical perspective is provided on the discovery of dopamine receptor segregation leading to models of how the direct and indirect affect motor behavior.

摘要

直接和间接纹状体通路构成了基底神经节回路的基石。由于直接和间接通路的棘状投射神经元中D1和D2多巴胺受体的分离，多巴胺对这些通路的功能具有相反的影响。本文提供了一个关于多巴胺受体分离发现的历史视角，从而引出直接和间接通路如何影响运动行为的模型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f60/9892636/d67624570d36/fnsyn-14-1002960-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f60/9892636/9ea52ca5336c/fnsyn-14-1002960-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f60/9892636/c756188e015a/fnsyn-14-1002960-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f60/9892636/5386bc97594e/fnsyn-14-1002960-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f60/9892636/beef8c253e25/fnsyn-14-1002960-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f60/9892636/6b23f2bc4a2f/fnsyn-14-1002960-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f60/9892636/da369157d39d/fnsyn-14-1002960-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f60/9892636/d67624570d36/fnsyn-14-1002960-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f60/9892636/9ea52ca5336c/fnsyn-14-1002960-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f60/9892636/c756188e015a/fnsyn-14-1002960-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f60/9892636/5386bc97594e/fnsyn-14-1002960-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f60/9892636/beef8c253e25/fnsyn-14-1002960-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f60/9892636/6b23f2bc4a2f/fnsyn-14-1002960-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f60/9892636/da369157d39d/fnsyn-14-1002960-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f60/9892636/d67624570d36/fnsyn-14-1002960-g007.jpg

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2
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Nature. 2021 Nov;599(7886):645-649. doi: 10.1038/s41586-021-04055-4. Epub 2021 Nov 3.
3
The mouse cortico-basal ganglia-thalamic network.鼠大脑皮层-基底神经节-丘脑网络。
间接通路的失调是否通过神经递质失衡导致紧张症的病理生理学？
Clin Neuropsychiatry. 2025 Jun;22(3):229-242. doi: 10.36131/cnfioritieditore20250306.
4
The regulation of rhythmic locomotion by motor cortical and dopaminergic inputs in the mouse striatum.小鼠纹状体中运动皮层和多巴胺能输入对节律性运动的调节。
Mol Brain. 2025 Jul 16;18(1):63. doi: 10.1186/s13041-025-01232-8.
5
The role of L-DOPA in neurological and neurodegenerative complications: a review.左旋多巴在神经和神经退行性并发症中的作用：综述
Mol Cell Biochem. 2025 Jun 9. doi: 10.1007/s11010-025-05324-w.
6
Striatal dopamine D2/D3 receptor regulation of human reward processing and behaviour.纹状体多巴胺D2/D3受体对人类奖赏加工和行为的调节
Nat Commun. 2025 Feb 21;16(1):1852. doi: 10.1038/s41467-025-56663-7.
7
Steady Moderate Exercise Confers Resilience Against Neurodegeneration and Neuroinflammation in a Mouse Model of Parkinson's Disease.在帕金森病小鼠模型中，持续适度运动可赋予对神经退行性变和神经炎症的抵抗力。
Int J Mol Sci. 2025 Jan 28;26(3):1146. doi: 10.3390/ijms26031146.
8
Regulation by Trace Amine-Associated Receptor 1 (TAAR1) of Dopaminergic-GABAergic Interaction in the Striatum: Effects of the Enhancer Drug (-)BPAP.纹状体中多巴胺能-γ-氨基丁酸能相互作用受痕量胺相关受体1（TAAR1）的调节：增强剂药物（-）BPAP的作用
Neurochem Res. 2025 Feb 4;50(2):94. doi: 10.1007/s11064-025-04337-7.
9
Characterizing drug-induced stuttering in electronic health records.在电子健康记录中表征药物性口吃。
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10
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Nature. 2021 Oct;598(7879):188-194. doi: 10.1038/s41586-021-03993-3. Epub 2021 Oct 6.
4
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Front Neural Circuits. 2021 Mar 2;15:645287. doi: 10.3389/fncir.2021.645287. eCollection 2021.
5
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J Neurosci. 2021 May 5;41(18):4036-4059. doi: 10.1523/JNEUROSCI.2210-20.2021. Epub 2021 Mar 17.
6
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J Neurosci. 2021 May 5;41(18):3966-3987. doi: 10.1523/JNEUROSCI.2306-20.2021. Epub 2021 Mar 17.
7
Divergent pallidal pathways underlying distinct Parkinsonian behavioral deficits.不同苍白球通路导致不同帕金森病行为缺陷。
Nat Neurosci. 2021 Apr;24(4):504-515. doi: 10.1038/s41593-021-00810-y. Epub 2021 Mar 15.
8
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9
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J Neurosci. 2021 Jan 27;41(4):711-725. doi: 10.1523/JNEUROSCI.1497-20.2020. Epub 2020 Dec 2.
10
Differential Synaptic Input to External Globus Pallidus Neuronal Subpopulations In Vivo.体内外苍白球神经元亚群的差异突触传入。
Neuron. 2021 Feb 3;109(3):516-529.e4. doi: 10.1016/j.neuron.2020.11.006. Epub 2020 Nov 27.