Laboratory of the Immunobiology of Inflammation, Department of Biological Sciences/Institute of Exact and Biological Sciences (ICEB), Federal University of Ouro Preto, Ouro Preto, MG, Brazil.
Graduate Program in Health and Nutrition, School of Nutrition, Federal University of Ouro Preto, Ouro Preto, MG, Brazil.
Front Immunol. 2023 Jan 18;14:1074760. doi: 10.3389/fimmu.2023.1074760. eCollection 2023.
To evaluate the available information on inflammatory and regulatory plasma mediators in pregnant women (PW) diagnosed with toxoplasmosis. Source: The PubMed, Embase, Scopus, and Lilacs databases were evaluated until October 2022. Study eligibility criteria: This review was carried out following the PRISMA and registered on the PROSPERO platform (CRD42020203951). Studies that reported inflammatory mediators in PW with toxoplasmosis were considered.
After excluding duplicate articles, two authors independently carried out the process of title and abstract exclusion, and a third resolved disagreements when necessary. The full text was evaluated to detect related articles. The extraction table was built from the following data: Author, year of publication, journal name and impact factors, country, study design, number of gestations and maternal age (years), gestational period, diagnosis of toxoplasmosis, levels of inflammatory markers, laboratory tests, and clinical significance. Methodological quality was assessed using Joanna Briggs Institute tools.
Of the 1,024 studies reported, only eight were included. Of the 868 PW included in this review, 20.2% were IgM+/IgG- and 50.8% were IgM-/IgG+ to , and 29.0% uninfected. Infected PW presented higher plasma levels ofIL-5, IL-6, IL-8, IL-17, CCL5, and IL-10. Regarding the methodological quality, four studies obtained high quality. Data from this review pointed out the maintenance of the inflammatory pattern during pregnancy with a closely related to the parasite.
Immune status in PW defined the course of the infection, where the equilibrium between inflammatory and regulatory cytokines mitigated the harmful placenta and fetus effects.
https://www.crd.york.ac.uk/prospero/, identifier CRD420203951.
评估诊断为弓形虫病的孕妇（PW）体内炎症和调节性血浆介质的现有信息。
评估了截至 2022 年 10 月的 PubMed、Embase、Scopus 和 Lilacs 数据库。研究入选标准：本综述遵循 PRISMA 进行，并在 PROSPERO 平台上注册（CRD42020203951）。考虑了报道 PW 弓形虫病炎症介质的研究。
在排除重复文章后，两名作者独立进行标题和摘要排除过程，如有必要，第三名作者解决分歧。评估全文以发现相关文章。从以下数据中构建提取表：作者、发表年份、期刊名称和影响因素、国家、研究设计、妊娠次数和产妇年龄（岁）、妊娠期、弓形虫病诊断、炎症标志物水平、实验室检查和临床意义。使用 Joanna Briggs 研究所工具评估方法学质量。
在报道的 1024 项研究中，仅纳入了 8 项。在本综述纳入的 868 名 PW 中，20.2%为 IgM+/IgG-，50.8%为 IgM-/IgG+，29.0%为未感染。感染的 PW 表现出更高的血浆 IL-5、IL-6、IL-8、IL-17、CCL5 和 IL-10 水平。关于方法学质量，四项研究获得了高质量。本综述的数据指出，在妊娠期间，免疫状态维持了弓形虫病的发展，与寄生虫之间存在密切关系。
PW 的免疫状态决定了弓形虫感染的过程，其中炎症和调节性细胞因子的平衡减轻了对胎盘和胎儿的有害影响。
https://www.crd.york.ac.uk/prospero/，标识符 CRD420203951。
