Efficacy of external application of oil and gel dosage forms of formulation in combination with in the management of (vitiligo) - An open-labeled comparative clinical trial.

INTRODUCTION

(ART) is one of the herbomineral formulations mentioned in Chakradatta indicated in (vitiligo). Modification of form into gel form reduces the risk of contamination in view of arsenical contents (, ) assures precise dose administration at desired site (by avoiding spreading). The gel is a comparatively acceptable dosage form than that of medicated oil.

AIM

The aim of the study is to evaluate the comparative efficacy of formulation in (ART: ) and gel (ARG: gel) dosage forms with the internal administration of in the management of .

MATERIALS AND METHODS

The study was a randomized open labeled, involving 66 patients of that were randomly divided into two groups. Patients registered in group A ( = 34) were treated with local applications of ART and group B ( = 32) with ARG for 2 months. (3 g), along with the equal quantity of honey and was given twice a day after the meal in both groups. Wilcoxon signed-rank test was applied to evaluate the effect of therapy in the individual group for subjective criteria like vitiligo area scoring index score, size and number of patches, (dryness), (burning sensation), (thickening), (itching) while the comparison of results between the groups for the same by applying Coefficient of Variation (CV).

RESULTS

Group B showed better and consistent results in all signs and symptoms except in terms of Coefficient of Variation. In both the groups, statistically highly significant improvement was found in signs and symptoms of such as , size of patches and number of patches; however, the difference between the groups was statistically insignificant.

CONCLUSION

Both the forms (ART, ARG) of formulation along with were found as a safe and effective treatment in vitiligo with significant pigment regeneration capacity as topical use for application over 2 months.