Makwana Sarika, Parekh Dipali, Bedarkar Prashant, Patgiri Biswajyoti
Department of Rasa Shastra and Bhaisajya Kalpana, ITRA, Gujarat Ayurved University, Jamnagar, Gujarat, India.
Ayu. 2021 Jan-Mar;42(1):19-29. doi: 10.4103/ayu.AYU_323_20. Epub 2022 Dec 7.
(ART) is one of the herbomineral formulations mentioned in Chakradatta indicated in (vitiligo). Modification of form into gel form reduces the risk of contamination in view of arsenical contents (, ) assures precise dose administration at desired site (by avoiding spreading). The gel is a comparatively acceptable dosage form than that of medicated oil.
The aim of the study is to evaluate the comparative efficacy of formulation in (ART: ) and gel (ARG: gel) dosage forms with the internal administration of in the management of .
The study was a randomized open labeled, involving 66 patients of that were randomly divided into two groups. Patients registered in group A ( = 34) were treated with local applications of ART and group B ( = 32) with ARG for 2 months. (3 g), along with the equal quantity of honey and was given twice a day after the meal in both groups. Wilcoxon signed-rank test was applied to evaluate the effect of therapy in the individual group for subjective criteria like vitiligo area scoring index score, size and number of patches, (dryness), (burning sensation), (thickening), (itching) while the comparison of results between the groups for the same by applying Coefficient of Variation (CV).
Group B showed better and consistent results in all signs and symptoms except in terms of Coefficient of Variation. In both the groups, statistically highly significant improvement was found in signs and symptoms of such as , size of patches and number of patches; however, the difference between the groups was statistically insignificant.
Both the forms (ART, ARG) of formulation along with were found as a safe and effective treatment in vitiligo with significant pigment regeneration capacity as topical use for application over 2 months.
（ART）是《恰克拉达塔》中提及的用于（白癜风）治疗的草药矿物配方之一。鉴于其含砷成分，将ART剂型改为凝胶剂型可降低污染风险，（，）确保在所需部位精确给药（避免扩散）。与药用油相比，凝胶是一种相对更易接受的剂型。
本研究旨在评估（ART：）剂型和凝胶（ARG：凝胶）剂型在联合内服时治疗白癜风的相对疗效。
本研究为随机开放标签试验，纳入66例白癜风患者，随机分为两组。A组（ = 34）患者接受ART局部治疗，B组（ = 32）患者接受ARG局部治疗，为期2个月。两组患者均在饭后每日两次服用（3克），并搭配等量蜂蜜和。采用Wilcoxon符号秩检验评估各治疗组在主观标准（如白癜风面积评分指数得分、斑块大小和数量、（干燥）、（烧灼感）、（增厚）、（瘙痒））方面的治疗效果，而通过应用变异系数（CV）比较两组间相同指标的结果。
除变异系数外，B组在所有体征和症状方面均显示出更好且更一致的结果。两组在白癜风的体征和症状（如、斑块大小和数量）方面均有统计学上的高度显著改善；然而，两组间差异无统计学意义。
发现（ART、ARG）两种剂型联合均是治疗白癜风的安全有效方法，作为局部用药使用2个月具有显著的色素再生能力。
