Role of in the therapeutic efficacy of along with in the treatment of (psoriasis): A double-blind randomised clinical trial.

INTRODUCTION

(RM) and (GG) are well-known formulations for treating skin disorders in . The drug RM is prepared from (processed orpiment) as a single ingredient. In the present study, RM was prepared from the , which was , with two different media, viz., and . In the classics, the preparation of RM is mentioned in the . However, the availability and cost of are the main points of concern in the present era. of by is more cost-effective than .

AIM

The aim of this study is to evaluate the comparative efficacy of RM prepared by (CSHRM) and RM prepared by (KSHRM) with GG in (psoriasis).

MATERIALS AND METHODS

The study was a randomized double-blind study involving 76 patients with that were randomly divided into two groups. Patients registered in group A (n = 37) were treated with CSHRM with GG (125 mg + 375 mg) and group B (n = 36) with KSHRM with GG (125 mg + 375 mg) for 8 weeks. The Wilcoxon signed rank test and paired t-test were applied to evaluate the effect of therapy in the individual group for subjective criteria like the PASI score, (looks like the scales of a fish), (dryness), (anhydrosis), (burning), (discharge), (raised patches), (itching), (broad-based), and (discoloration), while the comparison of results between the groups for the same was done by applying the Coefficient of Variation (CV).

RESULT

CSHRM with GG showed better results in all signs and symptoms except , , , , and DLQI in terms of the coefficient of variation. In both groups, statistically highly significant (P > 0.001) improvement was found in the signs and symptoms of . However, the difference between the groups was statistically nonsignificant.

CONCLUSION

prepared with both media along with was discovered to be a safe and effective psoriasis treatment.