变性关节疾病中的 RNA 结合蛋白：系统评价。
RNA-binding proteins in degenerative joint diseases: A systematic review.
机构信息
Department of Orthopedics, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.
Department of Pediatrics, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.
出版信息
Ageing Res Rev. 2023 Apr;86:101870. doi: 10.1016/j.arr.2023.101870. Epub 2023 Feb 4.
RNA-binding proteins (RBPs), which are conserved proteins comprising multiple intermediate sequences, can interact with proteins, messenger RNA (mRNA) of coding genes, and non-coding RNAs to perform different biological functions, such as the regulation of mRNA stability, selective polyadenylation, and the management of non-coding microRNA (miRNA) synthesis to affect downstream targets. This article will highlight the functions of RBPs, in degenerative joint diseases (intervertebral disc degeneration [IVDD] and osteoarthritis [OA]). It will reviews the latest advancements on the regulatory mechanism of RBPs in degenerative joint diseases, in order to understand the pathophysiology, early diagnosis and treatment of OA and IVDD from a new perspective.
RNA 结合蛋白（RBPs）是一类保守的蛋白质，由多个中间序列组成，可与蛋白质、编码基因的信使 RNA（mRNA）和非编码 RNA 相互作用，从而发挥不同的生物学功能，如调节 mRNA 稳定性、选择性多聚腺苷酸化以及管理非编码 microRNA（miRNA）的合成，以影响下游靶标。本文将重点介绍 RBPs 在退行性关节疾病（椎间盘退变[IVDD]和骨关节炎[OA]）中的作用，并综述 RBPs 在退行性关节疾病中的调控机制的最新进展，以期从新的视角理解 OA 和 IVDD 的病理生理学、早期诊断和治疗。
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