Department of Orthopedics, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.
Department of Pediatrics, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.
Ageing Res Rev. 2023 Apr;86:101870. doi: 10.1016/j.arr.2023.101870. Epub 2023 Feb 4.
RNA-binding proteins (RBPs), which are conserved proteins comprising multiple intermediate sequences, can interact with proteins, messenger RNA (mRNA) of coding genes, and non-coding RNAs to perform different biological functions, such as the regulation of mRNA stability, selective polyadenylation, and the management of non-coding microRNA (miRNA) synthesis to affect downstream targets. This article will highlight the functions of RBPs, in degenerative joint diseases (intervertebral disc degeneration [IVDD] and osteoarthritis [OA]). It will reviews the latest advancements on the regulatory mechanism of RBPs in degenerative joint diseases, in order to understand the pathophysiology, early diagnosis and treatment of OA and IVDD from a new perspective.
RNA 结合蛋白（RBPs）是一类保守的蛋白质，由多个中间序列组成，可与蛋白质、编码基因的信使 RNA（mRNA）和非编码 RNA 相互作用，从而发挥不同的生物学功能，如调节 mRNA 稳定性、选择性多聚腺苷酸化以及管理非编码 microRNA（miRNA）的合成，以影响下游靶标。本文将重点介绍 RBPs 在退行性关节疾病（椎间盘退变[IVDD]和骨关节炎[OA]）中的作用，并综述 RBPs 在退行性关节疾病中的调控机制的最新进展，以期从新的视角理解 OA 和 IVDD 的病理生理学、早期诊断和治疗。
