Ke Liting, Duan Xueqin, Cui Jing, Song Xiaoping, Ma Wuren, Zhang Weimin, Liu Yingqiu, Fan Yunpeng
College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, PR China.
College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, PR China.
Carbohydr Polym. 2023 Apr 15;306:120602. doi: 10.1016/j.carbpol.2023.120602. Epub 2023 Jan 18.
More pharmacological effects of polysaccharides from traditional Chinese medicines have been discovered in recent years. Epimedium has been used for thousands of years as a traditional Chinese medicine in China. Water-soluble Epimedium polysaccharides is one of the main ingredients of Epimedium, which is one of the main active ingredients of Epimedium, mainly composed of mannose, rhamnose, galacturonic acid, glucose, and galactose. The extraction methods of Epimedium polysaccharides including hot water extraction, cellulase extraction, ultrasonic extraction, microwave-assisted extraction, ultrasound compound enzyme and ultra-high pressure extraction, they affect the yield of Epimedium polysaccharides. The characteristics of deproteinization including enzyme deproteinization, macroporous resin deproteinization and Sevag methods are introduced respectively. Some chemical modification methods of Epimedium polysaccharides are also involved such as phosphorylation, sulfation, selenization, and lipids encapsulated. Epimedium polysaccharides have a variety of pharmacological activities, including immune promotion, reproduction promotion, anti-osteoporosis, anti-tumor, antioxidant, anti-fatigue and antivirus, also beneficial to nervous and hematopoietic systems. At present, the research of Epimedium polysaccharides has been in depth. In this paper, the research progress on extraction, purification, chemical modification methods and pharmacological activity of Epimedium polysaccharides summarized. The aim is to provide reference for further research and development of Epimedium polysaccharides.
近年来，人们发现了更多中药多糖的药理作用。淫羊藿在中国作为中药已使用了数千年。水溶性淫羊藿多糖是淫羊藿的主要成分之一，是淫羊藿的主要活性成分之一，主要由甘露糖、鼠李糖、半乳糖醛酸、葡萄糖和半乳糖组成。淫羊藿多糖的提取方法包括热水提取、纤维素酶提取、超声提取、微波辅助提取、超声复合酶和超高压提取，这些方法会影响淫羊藿多糖的产率。分别介绍了酶法脱蛋白、大孔树脂脱蛋白和Sevag法等脱蛋白的特点。还涉及淫羊藿多糖的一些化学修饰方法，如磷酸化、硫酸化、硒化和脂质包封。淫羊藿多糖具有多种药理活性，包括免疫促进、生殖促进、抗骨质疏松、抗肿瘤、抗氧化、抗疲劳和抗病毒，对神经和造血系统也有益。目前，淫羊藿多糖的研究已较为深入。本文综述了淫羊藿多糖在提取、纯化、化学修饰方法及药理活性方面的研究进展。目的是为淫羊藿多糖的进一步研发提供参考。
