State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
J Asian Nat Prod Res. 2023 Oct;25(10):919-940. doi: 10.1080/10286020.2023.2173181. Epub 2023 Feb 7.
Neolignans and lignans with diverse new chemical structures, including eleven pairs of separated chiral enantiomers [(+)-/(-)--(+)-/(-)-, (+)-/(-)-, (+)-/(-)-, and (+)-/(-)--(+)-/(-)-], two achiral compounds ( and ), and an unseparated racemate [(±)-], together with a new natural product () and 21 known derivatives, were isolated from an aqueous extract of the root head (guitou). Among the chiral isolates, (+)-/(-)- and (+)-/(-)- were scalemic pairs with enantiomeric ratios of around 3:1 and 1.5:1, respectively, while others were enantiomeric equivalent pairs. This indicates that the diverse neolignans in are biosynthesized via different pathways with varying degrees of stereo-controlled manners.
从鬼头（guitou）根茎的水提物中分离得到了 11 对对映异构体 [(+)-/(-)--(+)-/(-)-、(+)-/(-)-、(+)-/(-)-和 (+)-/(-)--(+)-/(-)-]、2 个非对映异构体（和）、1 个未拆分的外消旋体 [(±)-]、1 个新天然产物 () 和 21 个已知衍生物。其中，对映异构体 (+)-/(-)-和 (+)-/(-)-的对映体比例分别约为 3:1 和 1.5:1，为外消旋混合物，而其他对映异构体则为对映体等价物。这表明，鬼头根茎中的各种新木脂素是通过不同的生物合成途径，以不同程度的立体控制方式合成的。
