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结合分析流行病学和基因组监测,鉴定与血清型 Heidelberg 亚种中抗生素耐药性传播相关的危险因素。

Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in subsp. serovar Heidelberg.

机构信息

Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.

National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.

出版信息

Microb Genom. 2022 Nov;8(11). doi: 10.1099/mgen.0.000891.

Abstract

Antimicrobial resistance (AMR) has become a critical threat to public health worldwide. The use of antimicrobials in food and livestock agriculture, including the production of poultry, is thought to contribute to the dissemination of antibiotic resistant bacteria (ARB) and the genes and plasmids that confer the resistant phenotype (ARG). However, the relative contribution of each of these processes to the emergence of resistant pathogens in poultry production and their potential role in the transmission of resistant pathogens in human infections, requires a deeper understanding of the dynamics of ARB and ARG in food production and the factors involved in the increased risk of transmission.

摘要

抗菌药物耐药性(AMR)已成为全球公共卫生的一个重大威胁。人们认为,包括家禽生产在内的食品和家畜农业中抗菌药物的使用,助长了抗药性细菌(ARB)以及赋予耐药表型的基因和质粒(ARG)的传播。然而,这些过程中每一个过程对抗药性病原体在家禽生产中的出现的相对贡献,及其在人类感染中抗药性病原体传播的潜在作用,都需要深入了解食品生产中 ARB 和 ARG 的动态以及增加传播风险的相关因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/780b/9836098/27121fc56991/mgen-8-891-g001.jpg

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