Department of Biomedical Sciences, University of the State of Rio Grande do Norte, Aeroporto, Mossoró - RN, Brazil.
Department of Physiology, Federal University of Rio Grande do Norte; Campus Universitário UFRN - Lagoa Nova, Natal - RN, Brazil.
Acta Neurobiol Exp (Wars). 2022;82(4):448-461. doi: 10.55782/ane-2022-043.
Brain benefits from physical exercise associated with antioxidant supplements such as flaxseed oil. This low cost and simple association may improve hippocampal plasticity, which may work as a preventive and effective therapy in neuroprotection and neuroplasticity processes. This work evaluated the effects of physical exercise with flaxseed oil supplementation (Linum usitatissimum L.) in the hippocampus of Wistar rats. We separated male Wistar rats into four experimental groups: control group (sedentary), a sedentary group with a supplemental diet of flaxseed oil, a group under exercise program with flaxseed oil supplementation, and a group exclusively under exercise program. The swimming exercise consisted of a progressive 28‑day protocol followed by behavioral assessment, brain perfusion, microtomy, immunohistochemistry for glial fibrillary acidic protein (GFAP), cellular morphology, and optical density analysis. We used the ANOVA test with Tukey's post‑test for behavioral analysis. The exercise program with flaxseed oil supplementation was able to alter the GFAP expression in astrocytes in the CA1, CA3 and dentate gyrus regions of the hippocampus and modulate the behavioral aspects of memory and anxiety.
身体锻炼结合抗氧化补充剂（如亚麻籽油）对大脑有益。这种低成本且简单的联合作用可能改善海马体的可塑性，在神经保护和神经可塑性过程中作为一种预防和有效的治疗方法。本工作评估了身体锻炼结合亚麻籽油补充（Linum usitatissimum L.）对 Wistar 大鼠海马体的影响。我们将雄性 Wistar 大鼠分为四组：对照组（不运动）、不运动但补充亚麻籽油饮食组、运动结合亚麻籽油补充组和仅运动组。游泳运动包括一个渐进的 28 天方案，随后进行行为评估、脑灌注、微切、胶质纤维酸性蛋白（GFAP）免疫组织化学、细胞形态和光密度分析。我们使用方差分析和 Tukey 事后检验进行行为分析。结合亚麻籽油的运动方案能够改变海马体 CA1、CA3 和齿状回区的星形胶质细胞中的 GFAP 表达，并调节记忆和焦虑的行为方面。
