Programme Area Epidemiology and Health Services Research, German Rheumatism Research Centre Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany.
Z Rheumatol. 2024 Feb;83(Suppl 1):20-30. doi: 10.1007/s00393-022-01302-5. Epub 2023 Feb 7.
This study aimed to update the prevalence estimates of inflammatory rheumatic diseases (IRD) in Germany.
A systematic literature search in PubMed and Web of Science (last search 08 November 2022) identified original articles (regional and nationwide surveys and claims data analyses for arthritides, connective tissue diseases, and vasculitides) on prevalences for the period 2014-2022. Data sources, collection period, case definition, and risk of bias are reported. Prevalences were estimated from available national data, with consideration of international data.
Screening by two authors yielded 263 hits, of which 18 claims data analyses and 2 surveys met the inclusion criteria. Prevalences ranged from 0.42 to 1.85% (rheumatoid arthritis), 0.32-0.5% (ankylosing spondylitis), 0.11-0.32% (psoriatic arthritis), 0.037-0.14% (systemic lupus erythematosus), 0.07-0.77% (Sjögren's disease/sicca syndrome), 0.14-0.15% (polymyalgia rheumatica, ≥ 40 years), 0.04-0.05% (giant cell arteritis, ≥ 50 years), and 0.015-0.026% (ANCA-associated vasculitis). The risk of bias was moderate in 13 and high in 7 studies. Based on the results, we estimate the prevalence of IRD in Germany to be 2.2-3.0%, which corresponds to approximately 1.5-2.1 million affected individuals. The prevalence of juvenile idiopathic arthritis was reported to be around 0.10% (0.07-0.10%) of 0-18-year-olds, corresponding to about 14,000 children and adolescents in Germany.
This systematic review shows an increase in the prevalence of IRD in Germany, which is almost exclusively based on claims data analyses. In the absence of multistage population studies, the available data are, overall, uncertain sources for prevalence estimates, with a moderate to high risk of bias.
本研究旨在更新德国炎症性风湿病（IRD）的患病率估计。
在 PubMed 和 Web of Science（最近一次搜索时间为 2022 年 11 月 8 日）中进行系统文献检索，以确定 2014-2022 年期间有关关节炎、结缔组织病和血管炎的患病率的原始文章（区域和全国调查以及索赔数据分析）。报告了数据来源、收集期、病例定义和偏倚风险。考虑到国际数据，从可用的全国数据中估计了患病率。
两名作者进行筛选后得到 263 个结果，其中 18 项索赔数据分析和 2 项调查符合纳入标准。患病率范围为 0.42-1.85%（类风湿关节炎）、0.32-0.5%（强直性脊柱炎）、0.11-0.32%（银屑病关节炎）、0.037-0.14%（系统性红斑狼疮）、0.07-0.77%（干燥综合征/舍格伦综合征）、0.14-0.15%（多发性肌炎，≥40 岁）、0.04-0.05%（巨细胞动脉炎，≥50 岁）和 0.015-0.026%（抗中性粒细胞胞浆抗体相关性血管炎）。13 项研究的偏倚风险为中度，7 项研究的偏倚风险为高度。基于这些结果，我们估计德国 IRD 的患病率为 2.2-3.0%，这相当于约 150-210 万受影响的个体。据报道，幼年特发性关节炎在 0-18 岁人群中的患病率约为 0.10%（0.07-0.10%），相当于德国约 14000 名儿童和青少年。
本系统综述显示德国 IRD 的患病率有所增加，这几乎完全基于索赔数据分析。在缺乏多阶段人群研究的情况下，现有数据总体上是患病率估计的不确定来源，存在中度至高度偏倚风险。
