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银屑病关节炎患者的多学科治疗方法:一项前瞻性单中心队列研究。

Interdisciplinary approach to patients with psoriatic arthritis: a prospective, single-center cohort study.

作者信息

Gross Georg, Lull Christian, von Ahnen Jan Alwin, Blauth Mara, Schwaan Johanna, Olsavszky Victor, Schmieder Astrid, Leipe Jan

机构信息

Division of Rheumatology, Department of Medicine V, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.

Department of Dermatology, Venereology, and Allergology, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.

出版信息

Ther Adv Chronic Dis. 2024 Nov 28;15:20406223241293698. doi: 10.1177/20406223241293698. eCollection 2024.

Abstract

BACKGROUND

Psoriatic arthritis (PsA) is a chronic systemic inflammatory disease that affects up to 30% of patients with psoriasis. Diagnosis and treatment could be improved by implementing an interdisciplinary dermatological-rheumatological consultation (IDRC).

OBJECTIVES

This study aimed to assess the effect of a face-to-face IDRC involving both a dermatologist and a rheumatologist evaluating patients in a single visit, on disease activity and burden in patients with PsA.

DESIGN

Prospective, single-center, cohort study.

METHODS

202 patients with psoriasis were enrolled, among whom 115 individuals with psoriasis and musculoskeletal symptoms underwent an IDRC. Disease manifestations, comorbidities, and both objective and subjective disease activity scores were evaluated.

RESULTS

Out of the participants, 56 were diagnosed with definite PsA, while the remaining 146 had psoriasis. Nail involvement was associated with axial PsA (odds ratio 4.11; 95% CI 1.22-13.82;  = 0.02). Patients with PsA often experienced a prolonged time to diagnosis (mean 187 weeks) and had a significant psychosocial burden (mean Hospital Anxiety and Depression Index Scale [HADS]-Anxiety score of 7.66 and mean HADS-Depression score of 5.63). Post-IDRC, both objective and subjective disease parameters showed improvement, and patients required less time for consultations with healthcare professionals compared to before the IDRC.

CONCLUSION

These findings suggest that an IDRC approach could effectively expedite and optimize the diagnosis and treatment of patients with psoriasis and musculoskeletal symptoms.

摘要

背景

银屑病关节炎(PsA)是一种慢性全身性炎症性疾病,高达30%的银屑病患者会受到影响。实施跨学科皮肤科-风湿病咨询(IDRC)可改善诊断和治疗。

目的

本研究旨在评估由皮肤科医生和风湿病医生在单次就诊中共同评估患者的面对面IDRC对PsA患者疾病活动度和负担的影响。

设计

前瞻性、单中心队列研究。

方法

招募了202例银屑病患者,其中115例有银屑病和肌肉骨骼症状的患者接受了IDRC。评估了疾病表现、合并症以及客观和主观疾病活动评分。

结果

参与者中,56例被诊断为确诊PsA,其余146例患有银屑病。指甲受累与轴向PsA相关(比值比4.11;95%可信区间1.22 - 13.82;P = 0.02)。PsA患者的诊断时间通常较长(平均187周),且有显著的社会心理负担(医院焦虑和抑郁指数量表[HADS] - 焦虑平均评分为7.66,HADS - 抑郁平均评分为5.63)。IDRC后,客观和主观疾病参数均有改善,与IDRC前相比,患者与医护人员咨询所需时间减少。

结论

这些发现表明,IDRC方法可有效加快并优化对有银屑病和肌肉骨骼症状患者的诊断和治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f2f/11605746/0308a407e180/10.1177_20406223241293698-fig1.jpg

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