Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Elfriede-Aulhorn-Straße 6, Tübingen 72076, Germany.
Virus Res. 2023 Apr 2;327:199066. doi: 10.1016/j.virusres.2023.199066. Epub 2023 Feb 10.
The COVID-19 pandemic was officially announced in March 2020 and is still moving around the world. Virus strains, their pathogenicity and infectivity are changing, but the ability is fast to spread and harm people's health remained, despite the seasonality seasons and other circumstances. Most likely, humanity is doomed for a long time to coexistence with this emergent pathogen, since it is already circulating not only among the human population, but and among fauna, especially among wild animals in different regions of the planet. Thus, the range the virus has expanded, the material and conditions for its evolution are more than enough. The detection of SARS-CoV-2 in known infected fauna species is analyzed and possible spread and ongoing circulation of the virus in domestic and wild animals are discussed. One of the main focus of the article is the role of animal body temperature, its fluctuations and the presence of entry receptors in the susceptibility of different animal species to SARS-CoV-2 infection and virus spreading in possible new ecological niches. The possibility of long-term circulation of the pathogen among susceptible organisms is discussed.
2020 年 3 月正式宣布 COVID-19 大流行，目前仍在全球蔓延。病毒株及其致病性和传染性正在发生变化，但传播速度快、危害人类健康的能力依然存在，尽管存在季节性和其他情况。由于这种新发病原体不仅在人群中传播，而且在动物群中传播，特别是在地球上不同地区的野生动物中传播，因此，人类很可能注定要长期与之共存。因此，病毒的传播范围扩大，其进化的物质和条件绰绰有余。分析了已知感染动物物种中 SARS-CoV-2 的检测情况，并讨论了病毒在家养和野生动物中的传播和持续循环情况。本文的主要重点之一是动物体温、波动和进入受体的作用，不同动物物种对 SARS-CoV-2 感染的易感性以及可能在新生态位中的病毒传播。还讨论了病原体在易感生物中长期循环的可能性。
