Doctoral School of Health Sciences, Faculty of Health Science, University of Pẻcs, City of Pẻcs, Hungary.
Faculty of Health Sciences, University of Pécs, Hungary.
Biomed Pharmacother. 2023 Apr;160:114371. doi: 10.1016/j.biopha.2023.114371. Epub 2023 Feb 7.
Even though the pathophysiology of colorectal cancer (CRC) is complicated and poorly understood, interactions between risk factors appear to be key in the development and progression of the malignancy. The popularity of using lactic acid bacteria (LAB) prebiotics and probiotics to modulate the tumor microenvironment (TME) has grown widely over the past decade. The objective of this study was therefore to determine the detrimental effects of LAB-derived lactic acid in the colonic mucosa in colorectal cancer management. Six library databases and a web search engine were used to execute a structured systematic search of the existing literature, considering all publications published up until August 2022. A total of 7817 papers were screened, all of which were published between 1995 and August 2022. However, only 118 articles met the inclusion criterion. Lactic acid has been directly linked to the massive proliferation of cancerous cells since the glycolytic pathway provides cancerous cells with not only ATP, but also biosynthetic intermediates for rapid growth and proliferation. Our research suggests that targeting LAB metabolic pathways is capable of suppressing tumor growth and that the LDH gene is critical for tumorigenesis. Silencing of Lactate dehydrogenase, A (LDHA), B (LDHB), (LDHL), and hicD genes should be explored to inhibit fermentative glycolysis yielding lactic acid as the by-product. More studies are necessary for a solid understanding of this topic so that LAB and their corresponding lactic acid by-products do not have more adverse effects than their widely touted positive outcomes in CRC management.
尽管结直肠癌（CRC）的病理生理学复杂且尚未完全了解，但风险因素之间的相互作用似乎是恶性肿瘤发展和进展的关键。在过去十年中，广泛使用乳酸菌（LAB）益生元和益生菌来调节肿瘤微环境（TME）的方法越来越受欢迎。因此，本研究的目的是确定 LAB 衍生乳酸在结直肠癌管理中对结肠黏膜的有害影响。使用六个文库数据库和一个网络搜索引擎，对现有文献进行了结构化系统搜索，考虑了截至 2022 年 8 月发表的所有出版物。共筛选出 7817 篇论文，均发表于 1995 年至 2022 年 8 月。然而，只有 118 篇文章符合纳入标准。自糖酵解途径不仅为癌细胞提供 ATP，还为快速生长和增殖提供生物合成中间体以来，乳酸已被直接与癌细胞的大量增殖联系起来。我们的研究表明，靶向 LAB 代谢途径能够抑制肿瘤生长，而 LDH 基因对肿瘤发生至关重要。应探索沉默乳酸脱氢酶 A（LDHA）、B（LDHB）、（LDHL）和 hicD 基因，以抑制产生乳酸的发酵糖酵解。需要进行更多的研究，以深入了解这一主题，以便 LAB 及其相应的乳酸副产品不会对结直肠癌管理的广泛宣传的积极结果产生更多的不利影响。
