MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China.
Center for Healthcare Materials, Shaoxing Institute, Zhejiang University, Shaoxing, 312099, China.
Macromol Biosci. 2023 May;23(5):e2200577. doi: 10.1002/mabi.202200577. Epub 2023 Feb 19.
Traumatic brain injury (TBI), a major public health problem accompanied with numerous complications, usually leads to serve disability and huge financial burden. The adverse and unfavorable pathological environment triggers a series of secondary injuries, resulting in serious loss of nerve function and huge obstacle of endogenous nerve regeneration. With the advances in adaptive tissue regeneration biomaterials, regulation of detrimental microenvironment to reduce the secondary injury and to promote the neurogenesis becomes possible. The adaptive biomaterials could respond and regulate biochemical, cellular, and physiological events in the secondary injury, including excitotoxicity, oxidative stress, and neuroinflammation, to rebuild circumstances suitable for regeneration. In this review, the development of pathology after TBI is discussed, followed by the introduction of adaptive biomaterials based on various pathological characteristics. The adaptive biomaterials carried with neurotrophic factors and stem cells for TBI treatment are then summarized. Finally, the current drawbacks and future perspective of biomaterials for TBI treatment are suggested.
创伤性脑损伤（TBI）是一个严重的公共卫生问题，伴随着许多并发症，通常导致严重残疾和巨大的经济负担。不利和不良的病理环境引发一系列继发性损伤，导致严重的神经功能丧失和内源性神经再生的巨大障碍。随着适应性组织再生生物材料的进步，调节有害的微环境以减少继发性损伤和促进神经发生成为可能。适应性生物材料可以响应和调节继发性损伤中的生化、细胞和生理事件，包括兴奋性毒性、氧化应激和神经炎症，以重建适合再生的环境。在这篇综述中，讨论了 TBI 后的病理学发展，然后介绍了基于各种病理特征的适应性生物材料。接着总结了用于 TBI 治疗的携带神经营养因子和干细胞的适应性生物材料。最后，提出了生物材料治疗 TBI 的当前缺点和未来展望。
