Octavius Gilbert Sterling, Shakila Ayesha, Meliani Mariska, Halim Anita
Department of Pediatrics, Universitas Pelita Harapan, Jakarta, Indonesia.
Ann Pediatr Endocrinol Metab. 2023 Mar;28(1):10-19. doi: 10.6065/apem.2244170.085. Epub 2023 Feb 5.
This study aimed to describe the prevalence of vitamin D deficiency in Indonesian children and adolescents.
This was a meta-analysis of prevalence using the Hartung-Knapp-Sidik-Jonkman method with a random effects model. A prediction interval was used to estimate true effects. We searched PubMed, MEDLINE, Cochrane Library, Science Direct, Google Scholar, and 3 Indonesian databases (Indonesian Scientific Journal Database, Neliti, and Indonesia One Search). We included cross-sectional or case-control studies that provided data on the prevalence of vitamin D deficiency. We excluded case reports, case series, cohort studies, or studies outside Indonesia. We computed point prevalence by dividing the number of children with hypovitaminosis D by the total number of subjects in that study. This review was registered with PROSPERO (International Prospective Register of Systematic Reviews) (CRD42022329814).
Of 1,397 manuscripts identified, 7 were included in this review. A total of 5,870 children were included in this meta-analysis, ranging in age from 6 months to 19 years. The prevalence of hypovitaminosis D in Indonesia was calculated as 33% (95% confidence interval [CI], 9-56) and was higher in females (60% [95% CI, 58-62]) than in males (40% [95% CI, 38-42]). Mean serum vitamin D level was 22.74 ng/mL (95% CI, 16.95-30.51) with a prediction interval of 15.96 ng/mL to 29.52 ng/mL.
Vitamin D deficiency is a public health emergency in Indonesia. Strategies to detect and treat vitamin D deficiency in Indonesian children and adolescents should be implemented immediately.
本研究旨在描述印度尼西亚儿童和青少年维生素D缺乏症的患病率。
这是一项采用Hartung-Knapp-Sidik-Jonkman方法和随机效应模型对患病率进行的荟萃分析。使用预测区间来估计真实效应。我们检索了PubMed、MEDLINE、Cochrane图书馆、Science Direct、谷歌学术以及3个印度尼西亚数据库（印度尼西亚科学期刊数据库、Neliti和印度尼西亚一站式搜索）。我们纳入了提供维生素D缺乏症患病率数据的横断面研究或病例对照研究。我们排除了病例报告、病例系列、队列研究或印度尼西亚以外的研究。通过将维生素D缺乏症儿童数量除以该研究中的受试者总数来计算时点患病率。本综述已在PROSPERO（国际系统评价前瞻性注册库）注册（CRD42022329814）。
在识别出的1397篇手稿中，本综述纳入了7篇。本荟萃分析共纳入5870名儿童，年龄从6个月至19岁不等。印度尼西亚维生素D缺乏症患病率计算为33%（95%置信区间[CI]，9 - 56），女性（60%[95%CI，58 - 62]）高于男性（40%[95%CI，385 - 57]）。血清维生素D平均水平为22.74 ng/mL（95%CI，16.95 - 30.51），预测区间为15.96 ng/mL至29.52 ng/mL。
维生素D缺乏症在印度尼西亚是一个公共卫生紧急情况。应立即实施检测和治疗印度尼西亚儿童和青少年维生素D缺乏症的策略。
