Tu Yaofen, Mao Zujie
Department of Urology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China.
Cancer Invest. 2023 Apr;41(4):354-368. doi: 10.1080/07357907.2023.2179063. Epub 2023 Feb 16.
Neutrophil extracellular traps (NETs) could promote tumor growth and distant metastases. Molecular subtypes of bladder cancer were identified with consensus cluster analysis. A NETs-related prognostic signature was constructed with LASSO cox regression analysis. As a result, we identified three subtypes of bladder cancer, which had a distinct difference in prognosis, immune microenvironment, TIDE score, mRNAsi score and IC50 score. We also developed a prognostic signature based on 5 NETs-related genes, which had a good performance in clinical outcome prediction of bladder cancer. These results may provide more data about the vital role of NETs in bladder cancer.
中性粒细胞胞外陷阱（NETs）可促进肿瘤生长和远处转移。通过一致性聚类分析确定了膀胱癌的分子亚型。利用LASSO Cox回归分析构建了与NETs相关的预后特征。结果，我们鉴定出三种膀胱癌亚型，它们在预后、免疫微环境、TIDE评分、mRNAsi评分和IC50评分方面存在明显差异。我们还基于5个与NETs相关的基因开发了一种预后特征，其在膀胱癌临床结局预测方面表现良好。这些结果可能为NETs在膀胱癌中的重要作用提供更多数据。
