School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China; International Scientific and Technological Cooperation Base of Intelligent Biomaterials and Functional Fibers, Hangzhou 310018, China.
College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, China.
Acta Biomater. 2023 Apr 1;160:32-44. doi: 10.1016/j.actbio.2023.01.059. Epub 2023 Feb 9.
Diabetes chronic wound is a severe and frequently occurring medical issue in patients with diabetes that often leads to more serious complications. Microneedles (MNs) can be used for wound healing as they can effectively pierce the epidermis and inject drugs into the wound tissue. However, common MN patches cannot provide sufficient skin adhesion to prevent detachment from the wound area. Inspired by the barb hangnail microstructure of porcupine quills, a porcupine quill-like multilayer MN patch with an adhesive back patching for tissue adhesion and diabetic wound healing was designed. Sodium hyaluronate-modified CaO nanoparticles and metformin (hypoglycemic agent) were loaded into the polycaprolactone tips of MNs, endowing them with exceptional antibacterial ability and hypoglycemic effect. A flexible and adhesive back patching was formed by polyacrylamide-polydopamine/Cu composite hydrogel, which ensures that the MN patches do not peel off from the application sites and reduce bacterial infection. The bioinspired multilayer structure of MN patches exhibits satisfactory mechanical and antibacterial properties, which is a potential multifunctional dressing platform for promoting wound healing. STATEMENT OF SIGNIFICANCE: The porcupine quill-like microneedles (MNs) with PAM-PDA/Cu (PPC) composite hydrogel back patching have been fabricated, which can enhance the adhesion property of MNs to the skin through a physical interlock of multilayer MNs and chemical bonding of hydrogel patching. CaO-HA NPs and metformin were loaded into the polycaprolactone tips of MNs, endowing them with the exceptional antibacterial ability and hypoglycemic effect, which could accelerate diabetic wound healing. As a safe and effective strategy in transdermal delivery of drugs, the as-fabricated flexible multilayer MN patch with good antibacterial, hypoglycemic, and biocompatibility has been used to promote the healing of diabetic wound by releasing oxygen and inhibiting inflammation at the wound site.
糖尿病慢性伤口是糖尿病患者中一种严重且经常发生的医学问题，常导致更严重的并发症。微针 (MNs) 可用于伤口愈合，因为它们可以有效地刺穿表皮并将药物注入伤口组织。然而，常见的 MN 贴片不能提供足够的皮肤附着力以防止从伤口区域脱落。受豪猪刺的倒钩挂甲微观结构的启发，设计了一种具有粘性背贴的豪猪刺状多层 MN 贴片，用于组织粘附和糖尿病伤口愈合。将透明质酸钠修饰的 CaO 纳米粒子和二甲双胍（降血糖剂）装载到 MN 的聚己内酯尖端，赋予它们出色的抗菌能力和降血糖作用。聚丙烯酰胺-聚多巴胺/Cu 复合水凝胶形成了柔性且粘性的背贴，确保 MN 贴片不会从应用部位剥落，并减少细菌感染。MN 贴片的仿生多层结构表现出令人满意的机械和抗菌性能，是一种促进伤口愈合的潜在多功能敷料平台。
已经制造了具有 PAM-PDA/Cu (PPC) 复合水凝胶背贴的豪猪刺状微针 (MNs)，通过多层 MNs 的物理互锁和水凝胶贴片的化学结合，可以增强 MNs 对皮肤的附着力。将 CaO-HA NPs 和二甲双胍装载到 MN 的聚己内酯尖端，赋予它们出色的抗菌能力和降血糖作用，可加速糖尿病伤口愈合。作为药物经皮传递的一种安全有效的策略，所制造的具有良好抗菌、降血糖和生物相容性的柔性多层 MN 贴片通过在伤口部位释放氧气和抑制炎症来促进糖尿病伤口的愈合。
